COVID-19: immunopathology and its implications for therapy

被引：1155

作者：

Cao, Xuetao ^{[1
,2
]}

机构：

[1] Nankai Univ, Coll Life Sci, Lab Immun & Inflammat, Tianjin, Peoples R China

[2] Chinese Acad Med Sci, Inst Basic Med Sci, Dept Immunol, Ctr Immunotherapy, Beijing, Peoples R China

来源：

NATURE REVIEWS IMMUNOLOGY | 2020年 / 20卷 / 05期

关键词：

D O I：

10.1038/s41577-020-0308-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Severe coronavirus disease 2019 (COVID-19) is characterized by pneumonia, lymphopenia, exhausted lymphocytes and a cytokine storm. Significant antibody production is observed; however, whether this is protective or pathogenic remains to be determined. Defining the immunopathological changes in patients with COVID-19 provides potential targets for drug discovery and is important for clinical management.

引用

页码：269 / 270

页数：2

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