Comparison of arterial spin-labeling techniques and dynamic susceptibility-weighted contrast-enhanced MRI in perfusion imaging of normal brain tissue

被引：74

作者：

Weber, MA ^{[1
]}

Günther, M ^{[1
]}

Lichy, MP ^{[1
]}

Delorme, S ^{[1
]}

Bongers, A ^{[1
]}

Thilmann, C ^{[1
]}

Essig, M ^{[1
]}

Zuna, I ^{[1
]}

Schad, LR ^{[1
]}

Debus, J ^{[1
]}

Schlemmer, HP ^{[1
]}

机构：

[1] German Canc Res Ctr, Div Radiol Diagnost & Therapy, D-69120 Heidelberg, Germany

来源：

INVESTIGATIVE RADIOLOGY | 2003年 / 38卷 / 11期

关键词：

cerebral MR perfusion imaging; arterial spin-labeling; dynamic susceptibility-weighted contrast-enhanced MRI;

D O I：

10.1097/01.rli.0000084890.57197.54

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Objectives: To evaluate relative cerebral blood flow (rCBF) in normal brain tissue using arterial spin-labeling (ASL) methods and first-pass dynamic susceptibility-weighted contrast-enhanced (DSC) magnetic resonance imaging (MRI). Methods: Sixty-two patients with brain metastases were examined on a 1.5 T-system up to 6 times during routine follow-up after stereotactic radiosurgery. Perfusion values in normal gray and white matter were measured using the ASL techniques ITS-FAIR in 38 patients, Q2TIPS in 62 patients, and the first-pass DSC echo-planar (EPI) MRI after bolus administration of gadopentetate dimeglumine in 42 patients. Precision of the ASL sequences was tested in follow-up examinations in 10 healthy volunteers. Results: Perfusion values in normal brain tissue obtained by all sequences correlated well by calculating Pearson's correlation coefficients (P < 0.0001) and remained unchanged after stereotactic radiosurgery as shown by analysis of variance (P > 0.05). Conclusion: Both ASL and DSC EPI MRI yield highly comparable perfusion values in normal brain tissue.

引用

页码：712 / 718

页数：7

共 37 条

[1] Reduced transit-time sensitivity in noninvasive magnetic resonance imaging of human cerebral blood flow [J].

Alsop, DC ;

Detre, JA .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1996, 16 (06) :1236-1249

[2] Methodology of brain perfusion imaging [J].

Barbier, EL ;

Lamalle, L ;

Décorps, M .

JOURNAL OF MAGNETIC RESONANCE IMAGING, 2001, 13 (04) :496-520

[3] POSITRON EMISSION TOMOGRAPHY IN THE STUDY OF HUMAN-TUMORS [J].

BEANEY, RP .

SEMINARS IN NUCLEAR MEDICINE, 1984, 14 (04) :324-341

[4] Magnetic resonance perfusion imaging in acute ischemic stroke using continuous arterial spin labeling [J].

Chalela, JA ;

Alsop, DC ;

Gonzalez-Atavales, JB ;

Maldjian, JA ;

Kasner, SE ;

Detre, JA .

STROKE, 2000, 31 (03) :680-687

[5] Noninvasive MRI evaluation of cerebral blood flow in cerebrovascular disease [J].

Detre, JA ;

Alsop, DC ;

Vives, LR ;

Maccotta, L ;

Teener, JW ;

Raps, EC .

NEUROLOGY, 1998, 50 (03) :633-641

[6] QUALITATIVE MAPPING OF CEREBRAL BLOOD-FLOW AND FUNCTIONAL LOCALIZATION WITH ECHO-PLANAR MR-IMAGING AND SIGNAL TARGETING WITH ALTERNATING RADIO-FREQUENCY [J].

EDELMAN, RR ;

SIEWERT, B ;

DARBY, DG ;

THANGARAJ, V ;

NOBRE, AC ;

MESULAM, MM ;

WARACH, S .

RADIOLOGY, 1994, 192 (02) :513-520

[7]

Engenhart-Cabillic R, 1999, FRONT RADIAT THER ON, V33, P318

[8] Dynamic susceptibility contrast-enhanced echo-planar imaging of cerebral gliomas -: Effect of contrast medium extravasation [J].

Essig, M ;

Wenz, F ;

Scholdei, R ;

Brüning, R ;

Berchtenbreiter, C ;

Meurer, M ;

Knopp, MV .

ACTA RADIOLOGICA, 2002, 43 (04) :354-359

[9]

Fajardo L.F., 1988, Pathol Annu, V23, P297

[10]

Feldmann HJ, 1998, MED RAD DIA IMG, P47

← 1 2 3 4 →