共 30 条
Performance of Aβ1-40, Aβ1-42, Total Tau, and Phosphorylated Tau as Predictors of Dementia in a Cohort of Patients with Mild Cognitive Impairment
被引:81
作者:

Parnetti, Lucilla
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Perugia, Neurol Clin, Ctr Disturbi Memoria, Unita Valutat Alzheimer,Osped S Maria della Miser, I-06132 Perugia, Italy Univ Perugia, Neurol Clin, Ctr Disturbi Memoria, Unita Valutat Alzheimer,Osped S Maria della Miser, I-06132 Perugia, Italy

Chiasserini, Davide
论文数: 0 引用数: 0
h-index: 0
机构:
IRCCS Rome, Fdn S Lucia, Rome, Italy Univ Perugia, Neurol Clin, Ctr Disturbi Memoria, Unita Valutat Alzheimer,Osped S Maria della Miser, I-06132 Perugia, Italy

Eusebi, Paolo
论文数: 0 引用数: 0
h-index: 0
机构:
Dipartimento Epidemiol Reg Umbria, Perugia, Italy Univ Perugia, Neurol Clin, Ctr Disturbi Memoria, Unita Valutat Alzheimer,Osped S Maria della Miser, I-06132 Perugia, Italy

Giannandrea, David
论文数: 0 引用数: 0
h-index: 0
机构: Univ Perugia, Neurol Clin, Ctr Disturbi Memoria, Unita Valutat Alzheimer,Osped S Maria della Miser, I-06132 Perugia, Italy

Bellomo, Gianni
论文数: 0 引用数: 0
h-index: 0
机构:
Osped San Giovanni Battista, Foligno, Italy Univ Perugia, Neurol Clin, Ctr Disturbi Memoria, Unita Valutat Alzheimer,Osped S Maria della Miser, I-06132 Perugia, Italy

De Carlo, Claudia
论文数: 0 引用数: 0
h-index: 0
机构: Univ Perugia, Neurol Clin, Ctr Disturbi Memoria, Unita Valutat Alzheimer,Osped S Maria della Miser, I-06132 Perugia, Italy

Padiglioni, Chiara
论文数: 0 引用数: 0
h-index: 0
机构: Univ Perugia, Neurol Clin, Ctr Disturbi Memoria, Unita Valutat Alzheimer,Osped S Maria della Miser, I-06132 Perugia, Italy

Mastrocola, Sara
论文数: 0 引用数: 0
h-index: 0
机构: Univ Perugia, Neurol Clin, Ctr Disturbi Memoria, Unita Valutat Alzheimer,Osped S Maria della Miser, I-06132 Perugia, Italy

Lisetti, Viviana
论文数: 0 引用数: 0
h-index: 0
机构:
IRCCS Rome, Fdn S Lucia, Rome, Italy Univ Perugia, Neurol Clin, Ctr Disturbi Memoria, Unita Valutat Alzheimer,Osped S Maria della Miser, I-06132 Perugia, Italy

Calabresi, Paolo
论文数: 0 引用数: 0
h-index: 0
机构:
IRCCS Rome, Fdn S Lucia, Rome, Italy Univ Perugia, Neurol Clin, Ctr Disturbi Memoria, Unita Valutat Alzheimer,Osped S Maria della Miser, I-06132 Perugia, Italy
机构:
[1] Univ Perugia, Neurol Clin, Ctr Disturbi Memoria, Unita Valutat Alzheimer,Osped S Maria della Miser, I-06132 Perugia, Italy
[2] Dipartimento Epidemiol Reg Umbria, Perugia, Italy
[3] Osped San Giovanni Battista, Foligno, Italy
[4] IRCCS Rome, Fdn S Lucia, Rome, Italy
关键词:
Alzheimer's disease;
amyloid-beta;
1-40;
1-42;
biomarker;
cerebrospinal fluid;
dementia;
mild cognitive impairment;
phosphorylated tau;
total tau;
ALZHEIMERS ASSOCIATION WORKGROUPS;
CEREBROSPINAL-FLUID BIOMARKERS;
DIAGNOSTIC GUIDELINES;
NATIONAL INSTITUTE;
FOLLOW-UP;
DISEASE;
CSF;
RATIO;
BETA-AMYLOID((1-42));
RECOMMENDATIONS;
D O I:
10.3233/JAD-2011-111349
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
Mild cognitive impairment (MCI) is a common condition in the elderly which may remain stable along time (MCI-MCI) or evolve into Alzheimer's disease (MCI-AD) or other dementias. Cerebrospinal fluid (CSF) classical biomarkers, i.e., amyloid-beta 1-42 (A beta(1-42)), total tau (t-tau), and phosphorylated tau (p-tau) reflect the neuropathological changes taking place in AD brains, thus disclosing the disease in its prodromal phase. With the aim to evaluate the power of each biomarker and/or their combination in predicting AD progression, we have measured CSF A beta(1-40), A beta(1-42), t-tau, and p-tau in patients with AD, MCI-MCI, MCI-AD, and other neurological diseases without dementia (OND) followed up for four years. A beta(1-42) levels were significantly lower in AD and MCI-AD than in MCI-MCI. T-tau and p-tau levels were significantly increased in AD and MCI-AD versus OND and MCI-MCI. The A beta(1-42)/A beta(1-40) ratio showed a significant decrease in AD and MCI-AD as compared to MCI-MCI. Both A beta(1-42)/t-tau and A beta(1-42)/p-tau ratios showed significantly decreased values in AD and MCI-AD with respect to OND and MCI-MCI. A beta(1-42)/p-tau ratio was the best parameter for discriminating MCI-AD from MCI-MCI (sensitivity 81%, specificity 95%), being also correlated with the annual change rate in the Mini Mental State Examination annual change rate score (MMSE-ACR, r(S)=-0.71, p<0.0001). Survival analysis showed that 81% of MCI with a low A beta(1-42)/p-tau ratio (<1372) progressed to AD. The best model of logistic regression analysis retained A beta(1-42) and p-tau (sensitivity 75%, 95%CI: 70-80%; specificity 96%, 95%CI: 94-98%). We can conclude that A beta(1-42) and p-tau reliably predict conversion to AD in MCI patients.
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收藏
页码:229 / 238
页数:10
相关论文
共 30 条
[1]
The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
[J].
Albert, Marilyn S.
;
DeKosky, Steven T.
;
Dickson, Dennis
;
Dubois, Bruno
;
Feldman, Howard H.
;
Fox, Nick C.
;
Gamst, Anthony
;
Holtzman, David M.
;
Jagust, William J.
;
Petersen, Ronald C.
;
Snyder, Peter J.
;
Carrillo, Maria C.
;
Thies, Bill
;
Phelps, Creighton H.
.
ALZHEIMERS & DEMENTIA,
2011, 7 (03)
:270-279

Albert, Marilyn S.
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

DeKosky, Steven T.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Virginia, Dept Neurol, Charlottesville, VA USA
Univ Virginia, Off Dean, Charlottesville, VA USA Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

Dickson, Dennis
论文数: 0 引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Pathol, Jacksonville, FL 32224 USA Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

Dubois, Bruno
论文数: 0 引用数: 0
h-index: 0
机构:
Grp Hosp Pitie Salpetriere, Inst Memory & Alzheimers Dis, INSERM, Unit Cognit Neuroimagerie & Malad Due Cerveau, F-75634 Paris, France Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

Feldman, Howard H.
论文数: 0 引用数: 0
h-index: 0
机构:
Bristol Myers Squibb Neurosci, Wallingford, CT USA Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

Fox, Nick C.
论文数: 0 引用数: 0
h-index: 0
机构:
UCL, Inst Neurol, London, England Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

Gamst, Anthony
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USA Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

Holtzman, David M.
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Dept Neurol, St Louis, MO USA
Washington Univ, Knight Alzheimers Dis Res Ctr, St Louis, MO USA Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

Jagust, William J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

Petersen, Ronald C.
论文数: 0 引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Neurol, Rochester, MN USA Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

Snyder, Peter J.
论文数: 0 引用数: 0
h-index: 0
机构:
Brown Univ, Rhode Isl Hosp, Alpert Med Sch, Providence, RI 02903 USA
Brown Univ, Dept Neurol, Alpert Med Sch, Providence, RI 02912 USA Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

Carrillo, Maria C.
论文数: 0 引用数: 0
h-index: 0
机构:
Alzheimers Assoc, Chicago, IL USA Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

Thies, Bill
论文数: 0 引用数: 0
h-index: 0
机构:
Alzheimers Assoc, Chicago, IL USA Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

Phelps, Creighton H.
论文数: 0 引用数: 0
h-index: 0
机构:
NIA, Bethesda, MD 20892 USA Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
[2]
Cerebrospinal fluid β-amyloid(1-42) in Alzheimer disease -: Differences between early- and late-onset Alzheimer disease and stability during the course of disease
[J].
Andreasen, N
;
Hesse, C
;
Davidsson, P
;
Minthon, L
;
Wallin, A
;
Winblad, B
;
Vanderstichele, H
;
Vanmechelen, E
;
Blennow, K
.
ARCHIVES OF NEUROLOGY,
1999, 56 (06)
:673-680

Andreasen, N
论文数: 0 引用数: 0
h-index: 0
机构: Pitea River Valley Hosp, Dept Rehabil, SE-94128 Pitea, Sweden

Hesse, C
论文数: 0 引用数: 0
h-index: 0
机构: Pitea River Valley Hosp, Dept Rehabil, SE-94128 Pitea, Sweden

Davidsson, P
论文数: 0 引用数: 0
h-index: 0
机构: Pitea River Valley Hosp, Dept Rehabil, SE-94128 Pitea, Sweden

Minthon, L
论文数: 0 引用数: 0
h-index: 0
机构: Pitea River Valley Hosp, Dept Rehabil, SE-94128 Pitea, Sweden

Wallin, A
论文数: 0 引用数: 0
h-index: 0
机构: Pitea River Valley Hosp, Dept Rehabil, SE-94128 Pitea, Sweden

Winblad, B
论文数: 0 引用数: 0
h-index: 0
机构: Pitea River Valley Hosp, Dept Rehabil, SE-94128 Pitea, Sweden

Vanderstichele, H
论文数: 0 引用数: 0
h-index: 0
机构: Pitea River Valley Hosp, Dept Rehabil, SE-94128 Pitea, Sweden

Vanmechelen, E
论文数: 0 引用数: 0
h-index: 0
机构: Pitea River Valley Hosp, Dept Rehabil, SE-94128 Pitea, Sweden

Blennow, K
论文数: 0 引用数: 0
h-index: 0
机构: Pitea River Valley Hosp, Dept Rehabil, SE-94128 Pitea, Sweden
[3]
CSF markers for incipient Alzheimer's disease
[J].
Blennow, K
;
Hampel, H
.
LANCET NEUROLOGY,
2003, 2 (10)
:605-613

Blennow, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Gothenburg, Sahlgrenska Acad, Dept Clin Neurosci, Gothenburg, Sweden

Hampel, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Gothenburg, Sahlgrenska Acad, Dept Clin Neurosci, Gothenburg, Sweden
[4]
tau protein in cerebrospinal fluid - A biochemical marker for axonal degeneration in Alzheimer disease?
[J].
Blennow, K
;
Wallin, A
;
Agren, H
;
Spenger, C
;
Siegfried, J
;
Vanmechelen, E
.
MOLECULAR AND CHEMICAL NEUROPATHOLOGY,
1995, 26 (03)
:231-245

Blennow, K
论文数: 0 引用数: 0
h-index: 0
机构: GOTHENBURG UNIV,MOLNDAL HOSP,DEPT CLIN NEUROSCI,PSYCHIAT UNIT,S-43180 MOLNDAL,SWEDEN

Wallin, A
论文数: 0 引用数: 0
h-index: 0
机构: GOTHENBURG UNIV,MOLNDAL HOSP,DEPT CLIN NEUROSCI,PSYCHIAT UNIT,S-43180 MOLNDAL,SWEDEN

Agren, H
论文数: 0 引用数: 0
h-index: 0
机构: GOTHENBURG UNIV,MOLNDAL HOSP,DEPT CLIN NEUROSCI,PSYCHIAT UNIT,S-43180 MOLNDAL,SWEDEN

Spenger, C
论文数: 0 引用数: 0
h-index: 0
机构: GOTHENBURG UNIV,MOLNDAL HOSP,DEPT CLIN NEUROSCI,PSYCHIAT UNIT,S-43180 MOLNDAL,SWEDEN

Siegfried, J
论文数: 0 引用数: 0
h-index: 0
机构: GOTHENBURG UNIV,MOLNDAL HOSP,DEPT CLIN NEUROSCI,PSYCHIAT UNIT,S-43180 MOLNDAL,SWEDEN

Vanmechelen, E
论文数: 0 引用数: 0
h-index: 0
机构: GOTHENBURG UNIV,MOLNDAL HOSP,DEPT CLIN NEUROSCI,PSYCHIAT UNIT,S-43180 MOLNDAL,SWEDEN
[5]
VALIDITY OF SOME NEUROPSYCHOLOGICAL TESTS IN THE ASSESSMENT OF MENTAL DETERIORATION
[J].
CALTAGIRONE, C
;
GAINOTTI, G
;
MASULLO, C
;
MICELI, G
.
ACTA PSYCHIATRICA SCANDINAVICA,
1979, 60 (01)
:50-56

CALTAGIRONE, C
论文数: 0 引用数: 0
h-index: 0
机构: Clinic for Nervous and Mental Diseases, Catholic University, Rome

GAINOTTI, G
论文数: 0 引用数: 0
h-index: 0
机构: Clinic for Nervous and Mental Diseases, Catholic University, Rome

MASULLO, C
论文数: 0 引用数: 0
h-index: 0
机构: Clinic for Nervous and Mental Diseases, Catholic University, Rome

MICELI, G
论文数: 0 引用数: 0
h-index: 0
机构: Clinic for Nervous and Mental Diseases, Catholic University, Rome
[6]
Revising the definition of Alzheimer's disease: a new lexicon
[J].
Dubois, Bruno
;
Feldman, Howard H.
;
Jacova, Claudia
;
Cummings, Jeffrey L.
;
DeKosky, Steven T.
;
Barberger-Gateau, Pascale
;
Delacourte, Andre
;
Frisoni, Giovanni
;
Fox, Nick C.
;
Galasko, Douglas
;
Gauthier, Serge
;
Hampel, Harald
;
Jicha, Gregory A.
;
Meguro, Kenichi
;
O'Brien, John
;
Pasquier, Florence
;
Robert, Philippe
;
Rossor, Martin
;
Salloway, Steven
;
Sarazin, Marie
;
de Souza, Leonardo C.
;
Stern, Yaakov
;
Visser, Pieter J.
;
Scheltens, Philip
.
LANCET NEUROLOGY,
2010, 9 (11)
:1118-1127

Dubois, Bruno
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris 06, Paris, France
Grp Hosp Pitie Salpetriere, AP HP, Res Ctr,UMR S975, Inst Memory & Alzheimers Dis,Inst Brain & Spinal, F-75634 Paris, France Univ Paris 06, Paris, France

Feldman, Howard H.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ British Columbia, Div Neurol, Vancouver, BC V5Z 1M9, Canada
Yale Univ, Dept Neurol, New Haven, CT USA
Bristol Myers Squibb Neurosci, Wallingford, CT USA Univ Paris 06, Paris, France

Jacova, Claudia
论文数: 0 引用数: 0
h-index: 0
机构:
Univ British Columbia, Div Neurol, Vancouver, BC V5Z 1M9, Canada Univ Paris 06, Paris, France

Cummings, Jeffrey L.
论文数: 0 引用数: 0
h-index: 0
机构:
UCLA Easton Alzheimers Dis Res Ctr, Los Angeles, CA USA Univ Paris 06, Paris, France

DeKosky, Steven T.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Virginia, Dept Neurol, Charlottesville, VA USA Univ Paris 06, Paris, France

Barberger-Gateau, Pascale
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bordeaux 2, INSERM, U897, F-33076 Bordeaux, France Univ Paris 06, Paris, France

Delacourte, Andre
论文数: 0 引用数: 0
h-index: 0
机构:
Assoc Dev Appl Neurosci, Faches Thumesnil, France Univ Paris 06, Paris, France

Frisoni, Giovanni
论文数: 0 引用数: 0
h-index: 0
机构:
IRCCS, Brescia, Italy Univ Paris 06, Paris, France

Fox, Nick C.
论文数: 0 引用数: 0
h-index: 0
机构:
UCL, Inst Neurol, Dept Neurodegenerat, Dementia Res Ctr, London, England Univ Paris 06, Paris, France

Galasko, Douglas
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USA Univ Paris 06, Paris, France

Gauthier, Serge
论文数: 0 引用数: 0
h-index: 0
机构:
Douglas Hosp, McGill Ctr Studies Aging, Montreal, PQ, Canada Univ Paris 06, Paris, France

论文数: 引用数:
h-index:
机构:

Jicha, Gregory A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Kentucky, Alzheimers Dis Ctr, Lexington, KY USA Univ Paris 06, Paris, France

Meguro, Kenichi
论文数: 0 引用数: 0
h-index: 0
机构:
Tohoku Univ, Grad Sch Med, Dept Geriatr Behav Neurol, Sendai, Miyagi 980, Japan Univ Paris 06, Paris, France

O'Brien, John
论文数: 0 引用数: 0
h-index: 0
机构:
Newcastle Univ, Inst Ageing & Hlth, Wolfson Res Ctr, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England Univ Paris 06, Paris, France

Pasquier, Florence
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Lille Nord France UDSL, Equipes Accueil EA 2691, CHU, Lille, France Univ Paris 06, Paris, France

Robert, Philippe
论文数: 0 引用数: 0
h-index: 0
机构:
UNSA, Ctr Memoire Ressources & Rech CHU Nice, Nice, France Univ Paris 06, Paris, France

Rossor, Martin
论文数: 0 引用数: 0
h-index: 0
机构:
UCL, Inst Neurol, Dept Neurodegenerat, Dementia Res Ctr, London, England Univ Paris 06, Paris, France

Salloway, Steven
论文数: 0 引用数: 0
h-index: 0
机构:
Brown Univ, Dept Clin Neurosci, Providence, RI 02912 USA Univ Paris 06, Paris, France

Sarazin, Marie
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris 06, Paris, France
Grp Hosp Pitie Salpetriere, AP HP, Res Ctr,UMR S975, Inst Memory & Alzheimers Dis,Inst Brain & Spinal, F-75634 Paris, France Univ Paris 06, Paris, France

de Souza, Leonardo C.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris 06, Paris, France
Grp Hosp Pitie Salpetriere, AP HP, Res Ctr,UMR S975, Inst Memory & Alzheimers Dis,Inst Brain & Spinal, F-75634 Paris, France Univ Paris 06, Paris, France

Stern, Yaakov
论文数: 0 引用数: 0
h-index: 0
机构:
Presbyterian Hosp, Taub Inst, Cognit Neurosci Div, New York, NY USA Univ Paris 06, Paris, France

Visser, Pieter J.
论文数: 0 引用数: 0
h-index: 0
机构:
Maastricht Univ Med Ctr, Sch Mental Hlth & Neurosci, Alzheimer Ctr Limburg, Dept Psychiat & Neuropsychol, Maastricht, Netherlands
Vrije Univ Amsterdam Med Ctr, Dept Neurol, Amsterdam, Netherlands
Vrije Univ Amsterdam Med Ctr, Alzheimer Ctr, Amsterdam, Netherlands Univ Paris 06, Paris, France

论文数: 引用数:
h-index:
机构:
[7]
Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study
[J].
Hansson, O
;
Zetterberg, H
;
Buchhave, P
;
Londos, E
;
Blennow, K
;
Minthon, L
.
LANCET NEUROLOGY,
2006, 5 (03)
:228-234

Hansson, O
论文数: 0 引用数: 0
h-index: 0
机构: Univ Gothenburg, Sahlgrenska Univ Hosp, Inst Clin Neurosci, Dept Expt Neurosci, S-43180 Gothenburg, Sweden

Zetterberg, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Gothenburg, Sahlgrenska Univ Hosp, Inst Clin Neurosci, Dept Expt Neurosci, S-43180 Gothenburg, Sweden

Buchhave, P
论文数: 0 引用数: 0
h-index: 0
机构: Univ Gothenburg, Sahlgrenska Univ Hosp, Inst Clin Neurosci, Dept Expt Neurosci, S-43180 Gothenburg, Sweden

Londos, E
论文数: 0 引用数: 0
h-index: 0
机构: Univ Gothenburg, Sahlgrenska Univ Hosp, Inst Clin Neurosci, Dept Expt Neurosci, S-43180 Gothenburg, Sweden

Blennow, K
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Gothenburg, Sahlgrenska Univ Hosp, Inst Clin Neurosci, Dept Expt Neurosci, S-43180 Gothenburg, Sweden Univ Gothenburg, Sahlgrenska Univ Hosp, Inst Clin Neurosci, Dept Expt Neurosci, S-43180 Gothenburg, Sweden

Minthon, L
论文数: 0 引用数: 0
h-index: 0
机构: Univ Gothenburg, Sahlgrenska Univ Hosp, Inst Clin Neurosci, Dept Expt Neurosci, S-43180 Gothenburg, Sweden
[8]
Prediction of Alzheimer's disease using the CSF Aβ42/Aβ40 ratio in patients with mild cognitive impairment
[J].
Hansson, Oskar
;
Zetterberg, Henrik
;
Buchhave, Peder
;
Andreasson, Ulf
;
Londos, Elisabet
;
Minthon, Lennart
;
Blennow, Kaj
.
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS,
2007, 23 (05)
:316-320

Hansson, Oskar
论文数: 0 引用数: 0
h-index: 0
机构: Lund Univ, Dept Clin Sci Malmo, Clin Memory Res Unit, Malmo, Sweden

Zetterberg, Henrik
论文数: 0 引用数: 0
h-index: 0
机构: Lund Univ, Dept Clin Sci Malmo, Clin Memory Res Unit, Malmo, Sweden

Buchhave, Peder
论文数: 0 引用数: 0
h-index: 0
机构: Lund Univ, Dept Clin Sci Malmo, Clin Memory Res Unit, Malmo, Sweden

Andreasson, Ulf
论文数: 0 引用数: 0
h-index: 0
机构: Lund Univ, Dept Clin Sci Malmo, Clin Memory Res Unit, Malmo, Sweden

Londos, Elisabet
论文数: 0 引用数: 0
h-index: 0
机构: Lund Univ, Dept Clin Sci Malmo, Clin Memory Res Unit, Malmo, Sweden

Minthon, Lennart
论文数: 0 引用数: 0
h-index: 0
机构: Lund Univ, Dept Clin Sci Malmo, Clin Memory Res Unit, Malmo, Sweden

Blennow, Kaj
论文数: 0 引用数: 0
h-index: 0
机构: Lund Univ, Dept Clin Sci Malmo, Clin Memory Res Unit, Malmo, Sweden
[9]
Improved discrimination of AD patients using β-amyloid(1-42) and tau levels in CSF
[J].
Hulstaert, F
;
Blennow, K
;
Ivanoiu, A
;
Schoonderwaldt, HC
;
Riemenschneider, M
;
De Deyn, PP
;
Bancher, C
;
Cras, P
;
Wiltfang, J
;
Mehta, PD
;
Iqbal, K
;
Pottel, H
;
Vanmechelen, E
;
Vanderstichele, H
.
NEUROLOGY,
1999, 52 (08)
:1555-1562

Hulstaert, F
论文数: 0 引用数: 0
h-index: 0
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Blennow, K
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Ivanoiu, A
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Schoonderwaldt, HC
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Riemenschneider, M
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De Deyn, PP
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[10]
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
[J].
Jack, Clifford R., Jr.
;
Knopman, David S.
;
Jagust, William J.
;
Shaw, Leslie M.
;
Aisen, Paul S.
;
Weiner, Michael W.
;
Petersen, Ronald C.
;
Trojanowski, John Q.
.
LANCET NEUROLOGY,
2010, 9 (01)
:119-128

Jack, Clifford R., Jr.
论文数: 0 引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Radiol, Rochester, MN 55905 USA Mayo Clin, Dept Radiol, Rochester, MN 55905 USA

Knopman, David S.
论文数: 0 引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Neurol, Rochester, MN 55905 USA Mayo Clin, Dept Radiol, Rochester, MN 55905 USA

Jagust, William J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Berkeley, Sch Publ Hlth & Helen Wills, Inst Neurosci, Berkeley, CA 94720 USA Mayo Clin, Dept Radiol, Rochester, MN 55905 USA

Shaw, Leslie M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
Univ Penn, Sch Med, Inst Aging, Philadelphia, PA 19104 USA Mayo Clin, Dept Radiol, Rochester, MN 55905 USA

Aisen, Paul S.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA Mayo Clin, Dept Radiol, Rochester, MN 55905 USA

Weiner, Michael W.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, San Francisco, CA 94143 USA Mayo Clin, Dept Radiol, Rochester, MN 55905 USA

Petersen, Ronald C.
论文数: 0 引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Neurol, Rochester, MN 55905 USA Mayo Clin, Dept Radiol, Rochester, MN 55905 USA

Trojanowski, John Q.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
Univ Penn, Sch Med, Inst Aging, Philadelphia, PA 19104 USA Mayo Clin, Dept Radiol, Rochester, MN 55905 USA