Revising the definition of Alzheimer's disease: a new lexicon

被引：1407

作者：

Dubois, Bruno ^{[1
,2
]}

Feldman, Howard H. ^{[3
,4
,5
]}

Jacova, Claudia ^{[3
]}

Cummings, Jeffrey L. ^{[6
]}

DeKosky, Steven T. ^{[7
]}

Barberger-Gateau, Pascale ^{[8
]}

Delacourte, Andre ^{[9
]}

Frisoni, Giovanni ^{[10
]}

Fox, Nick C. ^{[11
]}

Galasko, Douglas ^{[12
]}

Gauthier, Serge ^{[13
]}

Hampel, Harald ^{[14
]}

Jicha, Gregory A. ^{[15
]}

Meguro, Kenichi ^{[16
]}

O'Brien, John ^{[17
]}

Pasquier, Florence ^{[18
]}

Robert, Philippe ^{[19
]}

Rossor, Martin ^{[11
]}

Salloway, Steven ^{[20
]}

Sarazin, Marie ^{[1
,2
]}

de Souza, Leonardo C. ^{[1
,2
]}

Stern, Yaakov ^{[21
]}

Visser, Pieter J. ^{[22
,23
,24
]}

Scheltens, Philip ^{[23
,24
]}

机构：

[1] Univ Paris 06, Paris, France

[2] Grp Hosp Pitie Salpetriere, AP HP, Res Ctr,UMR S975, Inst Memory & Alzheimers Dis,Inst Brain & Spinal, F-75634 Paris, France

[3] Univ British Columbia, Div Neurol, Vancouver, BC V5Z 1M9, Canada

[4] Yale Univ, Dept Neurol, New Haven, CT USA

[5] Bristol Myers Squibb Neurosci, Wallingford, CT USA

[6] UCLA Easton Alzheimers Dis Res Ctr, Los Angeles, CA USA

[7] Univ Virginia, Dept Neurol, Charlottesville, VA USA

[8] Univ Bordeaux 2, INSERM, U897, F-33076 Bordeaux, France

[9] Assoc Dev Appl Neurosci, Faches Thumesnil, France

[10] IRCCS, Brescia, Italy

[11] UCL, Inst Neurol, Dept Neurodegenerat, Dementia Res Ctr, London, England

[12] Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USA

[13] Douglas Hosp, McGill Ctr Studies Aging, Montreal, PQ, Canada

[14] Goethe Univ Frankfurt, Dept Psychiat Psychosomat Med & Psychotherapy, Frankfurt, Germany

[15] Univ Kentucky, Alzheimers Dis Ctr, Lexington, KY USA

[16] Tohoku Univ, Grad Sch Med, Dept Geriatr Behav Neurol, Sendai, Miyagi 980, Japan

[17] Newcastle Univ, Inst Ageing & Hlth, Wolfson Res Ctr, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[18] Univ Lille Nord France UDSL, Equipes Accueil EA 2691, CHU, Lille, France

[19] UNSA, Ctr Memoire Ressources & Rech CHU Nice, Nice, France

[20] Brown Univ, Dept Clin Neurosci, Providence, RI 02912 USA

[21] Presbyterian Hosp, Taub Inst, Cognit Neurosci Div, New York, NY USA

[22] Maastricht Univ Med Ctr, Sch Mental Hlth & Neurosci, Alzheimer Ctr Limburg, Dept Psychiat & Neuropsychol, Maastricht, Netherlands

[23] Vrije Univ Amsterdam Med Ctr, Dept Neurol, Amsterdam, Netherlands

[24] Vrije Univ Amsterdam Med Ctr, Alzheimer Ctr, Amsterdam, Netherlands

来源：

LANCET NEUROLOGY | 2010年 / 9卷 / 11期

关键词：

MILD COGNITIVE IMPAIRMENT; CEREBROSPINAL-FLUID BIOMARKERS; CSF-PHOSPHORYLATED-TAU; BETA-AMYLOID BURDEN; HIPPOCAMPAL ATROPHY; LEWY BODIES; CLINICAL-DIAGNOSIS; RESEARCH CRITERIA; OLDER PERSONS; DEMENTIA;

D O I：

10.1016/S1474-4422(10)70223-4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Alzheimer's disease (AD) is classically defined as a dual clinicopathological entity. The recent advances in use of reliable biomarkers of AD that provide in-vivo evidence of the disease has stimulated the development of new research criteria that reconceptualise the diagnosis around both a specific pattern of cognitive changes and structural/biological evidence of Alzheimer's pathology. This new diagnostic framework has stimulated debate about the definition of AD and related conditions. The potential for drugs to intercede in the pathogenic cascade of the disease adds some urgency to this debate. This paper by the International Working Group for New Research Criteria for the Diagnosis of AD aims to advance the scientific discussion by providing broader diagnostic coverage of the AD clinical spectrum and by proposing a common lexicon as a point of reference for the clinical and research communities. The cornerstone of this lexicon is to consider AD solely as a clinical and symptomatic entity that encompasses both predementia and dementia phases.

引用

页码：1118 / 1127

页数：10

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