Chimerism and central tolerance

被引：75

作者：

Sykes, M

机构：

[1] Bone Marrow Transplantation Section, Transplant. Biology Research Center, Massachusetts General Hospital East, Boston, MA 02129

来源：

CURRENT OPINION IN IMMUNOLOGY | 1996年 / 8卷 / 05期

关键词：

D O I：

10.1016/S0952-7915(96)80088-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

With adequate depletion or inactivation of the pre-existing immune system and establishment of conditions permitting donor hematopoietic stem cell engraftment, a robust state of central deletional tolerance to allogeneic or xenogeneic donors can be induced. Advances have been made in the ability to achieve this permissive state without toxic, myeloablative conditioning, thus bringing this approach closer to clinical application.

引用

页码：694 / 703

页数：10

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