Integrins in angiogenesis and lymphangiogenesis

被引：816

作者：

Avraamides, Christie J. ^{[1
]}

Garmy-Susini, Barbara ^{[1
]}

Varner, Judith A. ^{[1
]}

机构：

[1] Moores UCSD Canc Ctr, La Jolla, CA 92092 USA

来源：

NATURE REVIEWS CANCER | 2008年 / 8卷 / 08期

关键词：

D O I：

10.1038/nrc2353

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Blood vessels promote tumour growth, and both blood and lymphatic vessels facilitate tumour metastasis by serving as conduits for the transport of tumour cells to new sites. Angiogenesis and lymphangiogenesis are regulated by integrins, which are members of a family of cell surface receptors whose ligands are extracellular matrix proteins and immunoglobulin superfamily molecules. Select integrins promote endothelial cell migration and survival during angiogenesis and lymphangiogenesis, whereas other integrins promote pro-angiogenic macrophage trafficking to tumours. Several integrin-targeted therapeutic agents are currently in clinical trials for cancer therapy. Here, we review the evidence implicating integrins as a family of fundamental regulators of angiogenesis and lymphangiogenesis.

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收藏

页码：604 / 617

页数：14

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