Restoration of fertility in young obese (Lepob Lepob) male mice with low dose recombinant mouse leptin treatment

被引：16

作者：

Cleary, MP ^{[1
]}

Bergstrom, HM ^{[1
]}

Dodge, TL ^{[1
]}

Getzin, SC ^{[1
]}

Jacobson, MK ^{[1
]}

Phillips, FC ^{[1
]}

机构：

[1] Univ Minnesota, Hormel Inst, Austin, MN 55912 USA

来源：

INTERNATIONAL JOURNAL OF OBESITY | 2001年 / 25卷 / 01期

关键词：

leptin; obese; male mice; fertility; Lep(ob) Lep(ob);

D O I：

10.1038/sj.ijo.0801525

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE: We investigated the effects of low-dose leptin treatment on restoration of fertility in young adult male leptin deficient obese mice. EXPERIMENTAL DESIGN AND RESULTS: MMTV-TCF-alpha Lep(ob) Lep(ob) mice (8-10 weeks old) were treated with recombinant mouse leptin. In experiment 1, four mice (5 mug/g body weight leptin followed by 2.5 mug/g) lost weight and impregnated females (number of pregnancies/number of females, 3/6, 5/6, 5/10, 4/10). In experiment 2, Leptin-Obese (2.5 mug/g) and Control-Lean mice weighed significantly less than Control-Obese mice. Epididymal pad weights of Control-Obese mice were the heaviest, followed by those of Leptin-Obese mice, and Control-Lean mice were the lightest. Testes weight was greater in Control-Lean vs Control-Obese mice. Leptin-Obese mice had testes weight not significantly different from either control group. Four of five Leptin-Obese mice impregnated females (4/10, 5/10, 2/10, 5/12, 0/10). CONCLUSIONS: These results indicate that low-dosage mouse recombinant leptin treatment restored fertility to young Lepob Lep(ob) male mice. Although body weights of Leptin-Obese mice were similar to those of lean age-matched mice, epididymal fat pad weights were heavier.

引用

页码：95 / 97

页数：3

共 19 条

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