Brain areas activated in fMRI during self-regulation of slow cortical potentials (SCPs)

被引:59
作者
Hinterberger, T
Veit, R
Strehl, U
Trevorrow, T
Erb, M
Kotchoubey, B
Flor, H
Birbaumer, N
机构
[1] Univ Tubingen, Inst Med Psychol & Behav Neurobiol, D-72074 Tubingen, Germany
[2] Univ Trent, Ctr Cognit Neurosci, I-01238100 Trent, Italy
[3] Chaminade Univ, Dept Psychol, Honolulu, HI 96816 USA
[4] Univ Tubingen, Dept Neuroradiol, CNS, Sect Expt Magnet Resonance, D-7400 Tubingen, Germany
[5] Univ Heidelberg, Cent Inst Mental Hlth, Dept Clin & Cognit Neurosci, D-68159 Mannheim, Germany
关键词
functional magnetic resonance imaging (fMRI); physiological regulation; slow cortical potentials (SCPs);
D O I
10.1007/s00221-003-1515-4
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In humans, surface-negative slow cortical potentials (SCPs) originating in the apical dendritic layers of the neocortex reflect synchronized depolarization of large groups of neuronal assemblies. They are recorded during states of behavioural or cognitive preparation and during motivational states of apprehension and fear. Surface positive SCPs are thought to indicate reduction of cortical excitation of the underlying neural networks and appear during behavioural inhibition and motivational inertia (e.g. satiety). SCPs at the cortical surface constitute summated population activity of local field potentials (LFPs). SCPs and LFPs may share identical neural substrates. In this study the relationship between negative and positive SCPs and changes in the BOLD signal of the fMRI were examined in ten subjects who were trained to successfully self-regulate their SCPs. FMRI revealed that the generation of negativity (increased cortical excitation) was accompanied by widespread activation in central, pre-frontal, and parietal brain regions as well as the basal ganglia. Positivity (decreased cortical excitation) was associated with widespread deactivations in several cortical sites as well as some activation, primarily in frontal and parietal structures as well as insula and putamen. Regression analyses revealed that cortical positivity was predicted with high accuracy by pallidum and putamen activation and supplementary motor area (SMA) and motor cortex deactivation, while differentiation between cortical negativity and positivity was revealed primarily in parahippocampal regions. These data suggest that negative and positive electrocortical potential shifts in the EEG are related to distinct differences in cerebral activation detected by fMRI and support animal studies showing parallel activations in fMRI and neuroelectric recordings.
引用
收藏
页码:113 / 122
页数:10
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