Kinetochore-spindle microtubulle interactions during mitosis

被引:89
作者
Kline-Smith, SL [1 ]
Sandall, S [1 ]
Desai, A [1 ]
机构
[1] Univ Calif San Diego, Dept Cell & Mol Med, Ludwig Inst Canc Res, La Jolla, CA 92093 USA
关键词
D O I
10.1016/j.ceb.2004.12.009
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The kinetochore is a proteinaceous structure that assembles onto centromeric DNA and mediates chromosome attachment to microtubules during mitosis. This description is deceivingly simple: recent proteomic studies suggest that the diminutive kinetochores of Saccharomyces cerevisiae are comprised of at least 60 proteins organized into as many as 14 different subcomplexes. Many of these proteins, such as the centromeric histone variant CENP-A, and entire subcomplexes, such as the Ndc80(Hec1) complex, are conserved from yeast to humans despite the diverse nature of the DNA sequences on which they assemble. There have recently been advances in our understanding of the molecular basis of how kinetochores establish dynamic attachments to spindle microtubules, and how these attachments are correctly oriented to ensure segregation of sister chromatids to daughter cells.
引用
收藏
页码:35 / 46
页数:12
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