Calcium channels and Ca2+ fluctuations in sperm physiology

被引:141
作者
Darszon, A [1 ]
Nishigaki, T [1 ]
Wood, C [1 ]
Treviño, CL [1 ]
Felix, R [1 ]
Beltrán, C [1 ]
机构
[1] Natl Polytech Inst, Ctr Res & Adv Studies, Dept Physiol, Mexico City 07300, DF, Mexico
来源
INTERNATIONAL REVIEW OF CYTOLOGY - A SURVEY OF CELL BIOLOGY, VOL 243 | 2005年 / 243卷
基金
英国惠康基金;
关键词
sperm Ca2+ channels; acrosome reaction; spermatogenesis; sperm motility; chemotaxis; sperm capacitation; ion channels; single-cell imaging;
D O I
10.1016/S0074-7696(05)43002-8
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Generating new life in animals by sexual reproduction depends on adequate communication between mature and competent male and female gametes. Ion channels are instrumental in the dialogue between sperm, its environment, and the egg. The ability of sperm to swim to the egg and fertilize it is modulated by ion permeability changes induced by environmental cues and components of the egg outer layer. Ca2+ is probably the key messenger in this information exchange. It is therefore not surprising that different Ca2+-permeable channels are distinctly localized in these tiny specialized cells. New approaches to measure sperm currents, intracellular Ca2+ membrane potential, and intracellular pH with fluorescent probes, patch-clamp recordings, sequence information, and heterologous expression are revealing how sperm channels participate in fertilization. Certain sperm ion channels are turning out to be unique, making them attractive targets for contraception and for the discovery of novel signaling complexes.
引用
收藏
页码:79 / 172
页数:94
相关论文
共 603 条
  • [71] CARAFOLI E, 1987, ANNU REV BIOCHEM, V56, P395, DOI 10.1146/annurev.biochem.56.1.395
  • [72] SPERACT RECEPTORS ARE LOCALIZED ON SEA-URCHIN SPERM FLAGELLA USING A FLUORESCENT PEPTIDE ANALOG
    CARDULLO, RA
    HERRICK, SB
    PETERSON, MJ
    DANGOTT, LJ
    [J]. DEVELOPMENTAL BIOLOGY, 1994, 162 (02) : 600 - 607
  • [73] CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm
    Carlson, AE
    Westenbroek, RE
    Quill, T
    Ren, DJ
    Clapham, DE
    Hille, B
    Garbers, DL
    Babcock, DF
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (25) : 14864 - 14868
  • [74] Transient receptor potential (TRPC) channels in human sperm:: expression, cellular localization and involvement in the regulation of flagellar motility
    Castellano, LE
    Treviño, CL
    Rodríguez, D
    Serrano, CJ
    Pacheco, J
    Tsutsumi, V
    Felix, R
    Darszon, A
    [J]. FEBS LETTERS, 2003, 541 (1-3) : 69 - 74
  • [75] Interactions of presynaptic Ca2+ channels and snare proteins in neurotransmitter release
    Catterall, WA
    [J]. MOLECULAR AND FUNCTIONAL DIVERSITY OF ION CHANNELS AND RECEPTORS, 1999, 868 : 144 - 159
  • [76] International Union of Pharmacology. XL. Compendium of voltage-gated ion channels: Calcium channels
    Catterall, WA
    Striessnig, J
    Snutch, TP
    Perez-Reyes, E
    [J]. PHARMACOLOGICAL REVIEWS, 2003, 55 (04) : 579 - 581
  • [77] Structure and regulation of voltage-gated Ca2+ channels
    Catterall, WA
    [J]. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2000, 16 : 521 - 555
  • [78] Human and mouse proteomic databases: novel resources in the protein universe
    Celis, JE
    Ostergaard, M
    Jensen, NA
    Gromova, I
    Rasmussen, HH
    Gromov, P
    [J]. FEBS LETTERS, 1998, 430 (1-2): : 64 - 72
  • [79] Expression of sperm Ca2+-activated K+ channels in Xenopus oocytes and their modulation by extracellular ATP
    Chan, HC
    Wu, WL
    Sun, YP
    Leung, PS
    Wong, TP
    Chung, YW
    So, SC
    Zhou, TS
    Yan, YC
    [J]. FEBS LETTERS, 1998, 438 (03) : 177 - 182
  • [80] Cation and anion channels in fat and human spermatozoa
    Chan, HC
    Zhou, TS
    Fu, WO
    Wang, WP
    Shi, YL
    Wong, PYD
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1997, 1323 (01): : 117 - 129