A facile and practical solid-phase synthesis of trisubstituted 2-aminoimidazolones

被引：24

作者：

Li, M ^{[1
]}

Wilson, LJ ^{[1
]}

机构：

[1] Procter & Gamble Co, Pharmaceut Hlth Care Res Ctr, Mason, OH 45040 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 08期

关键词：

2-aminoimidazolone; solid-phase synthesis; cyclizative-cleavage;

D O I：

10.1016/S0040-4039(00)02305-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The solid-phase synthesis of trisubstituted 2-aminoimidazolones based on the intramolecular cyclization between a delta -guanidinium nitrogen and the amide carbonyl under acidic conditions is described. The method utilizes easily accessible commercial starting materials, mild reaction conditions, as well as a cyclizative-cleavage strategy to afford the desired products in moderate to good overall yields and good to excellent purity. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1455 / 1458

页数：4

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