Solid-phase synthesis of 2-aminoimidazolones

被引：22

作者：

Fu, MM ^{[1
]}

Fernandez, M ^{[1
]}

Smith, ML ^{[1
]}

Flygare, JA ^{[1
]}

机构：

[1] Tularik Inc, San Francisco, CA 94080 USA

来源：

ORGANIC LETTERS | 1999年 / 1卷 / 09期

关键词：

D O I：

10.1021/ol990910p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A solid-phase route for the preparation of 2-aminoimidazolones has been developed which can incorporate diverse functionality at each position of the molecule. Resin-hound S-methyl isothioureas were converted to structures of type I by using commercially available Fmoc-protected amino acids, Products of structure II were accessed by reaction of the S-methyl isothiourea with 5-substituted oxazolones.

引用

页码：1351 / 1353

页数：3

共 13 条

[1]

Breton JJ, 1997, J PHARMACOL EXP THER, V282, P459

[2] SYNTHESIS OF 2-DIMETHYLAMINOIMIDAZOLE DERIVATIVES - A NEW ACCESS TO INDOLYL-IMIDAZOLE ALKALOIDS OF MARINE ORIGIN [J].