Observation of resolved glucose signals in H-1 NMR spectra of the human brain at 4 Tesla

Measurement of the resonances of glucose between 3.2 and 3.9 ppm in H-1 NMR spectra from the human brain is difficult due to spectral overlap with peaks from more concentrated metabolites, The H1 resonance of alpha-D-glucose at 5.23 ppm is resolved from other metabolite peaks, but potentially overlaps with the intense water signal at 4.72 ppm. This paper demonstrates that the increased resolution at 4 Tesla permits to suppress the water signal sufficiently to reliably detect glucose directly at 5.23 ppm by H-1 MRS and the estimated peak intensity is consistent with previous C-13 NMR quantification.