Protection of mice against lethal coxsackievirus B3 infection by using DNA immunization

被引：46

作者：

Henke, A

Wagner, E

Whitton, JL

Zell, R

Stelzner, A

机构：

[1] Friedrich Schiller Univ, Inst Virol, Med Ctr, D-07745 Jena, Germany

[2] Scripps Res Inst, Dept Neuropharmacol, La Jolla, CA 92037 USA

来源：

JOURNAL OF VIROLOGY | 1998年 / 72卷 / 10期

关键词：

D O I：

10.1128/JVI.72.10.8327-8331.1998

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Vaccination with DNA and recombinant vaccinia viruses (rec.VV) has been studied with the coxsackievirus B3 (CVB3) model system. Plasmids encoding all structural proteins of CVB3, when injected intramuscularly, induced only low levels of virus-specific antibodies. However, DNA vaccination with the major structural protein VP1 protected 72.2% of mice from lethal challenge, whereas VP1 expressed by rec.VV was much less efficient.

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收藏

页码：8327 / 8331

页数：5

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