Application of organolithium and related reagents in synthesis.: Part 22.: Synthetic strategies based on ortho-aromatic metallation.: A concise regiospecific conversion of benzoic acids into the 4-pyridyl-2H-phthalazin-1-ones.

被引：9

作者：

Brzezinski, JZ ^{[1
]}

Epsztajn, J ^{[1
]}

Bakalarz, AD ^{[1
]}

Lajszczak, A ^{[1
]}

Malinowski, Z ^{[1
]}

机构：

[1] Univ Lodz, Dept Organ Chem, PL-90136 Lodz, Poland

来源：

SYNTHETIC COMMUNICATIONS | 1999年 / 29卷 / 03期

关键词：

D O I：

10.1080/00397919908085788

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of phthalazin-1-ones 6, 7, 8 via the reaction of 3-hydroxyisoindolin-1-ones 3, 4, 5 with hydrazine hydrate is described. Starting compounds 3, 4, 5 were regiospecifically prepared upon the lithiation (n-BuLi) of the benzanilides 1 and subsequently the reaction of the dilithiated anilides 2 with methyl pyridinecarboxylates.

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页码：457 / 473

页数：17

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