Optimum treatment strategies for carbapenem-resistant Acinetobacter baumannii bacteremia

被引：58

作者：

Garnacho-Montero, Jose ^{[1
,2
,3
]}

Amaya-Villar, Rosario ^{[1
,2
,3
]}

Ferrandiz-Millon, Carmen ^{[1
]}

Diaz-Martin, Ana ^{[1
,2
]}

Maria Lopez-Sanchez, Jose ^{[1
]}

Gutierrez-Pizarraya, Antonio ^{[2
,3
]}

机构：

[1] Hosp Univ Virgen del Rocio, Unidad Clin Cuidados Crit, Seville, Spain

[2] Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Inst Biomed Sevilla IBiS, Seville, Spain

[3] Hosp Univ Virgen del Rocio, REIPI, Seville, Spain

来源：

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY | 2015年 / 13卷 / 06期

关键词：

Acinetobacter baumannii; bacteremia; carbapenem-resistant; colistin; polymyxin; tigecycline; treatment; CRITICALLY-ILL PATIENTS; VENTILATOR-ASSOCIATED PNEUMONIA; IN-VITRO ACTIVITY; GRAM-NEGATIVE BACTERIA; EXTENSIVELY DRUG-RESISTANT; ANTIMICROBIAL SURVEILLANCE PROGRAM; SUSCEPTIBILITY TESTING METHODS; BLOOD-STREAM INFECTIONS; INTRAVENOUS POLYMYXIN-B; ACUTE KIDNEY INJURY;

D O I：

10.1586/14787210.2015.1032254

中图分类号：

R51 [传染病];

学科分类号：

100201 [内科学];

摘要：

Carbapenem-resistant Acinetobacter baumannii (CRAB) constitutes an increasing problem worldwide. CRAB bacteremia is associated with a high fatality rate and its optimal treatment has not been established. Early institution of appropriate therapy is shown to improve survival of patients with CRAB bloodstream infection. Regrettably, treatment options are limited. Little information exists about the efficacy of sulbactam for the treatment of CRAB bacteremia. Colistin and tigecycline possess good in vitro activity and represent in many cases the only therapeutic options although clinical data are scarce. The need for a loading dose of colistin has been recently demonstrated to rapidly achieve therapeutic levels. The use of combination therapy is also a matter of debate but current evidence do not support its routine use.

引用

页码：769 / 777

页数：9

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