Higher Incidence of Acute Kidney Injury With Intravenous Colistimethate Sodium Compared With Polymyxin B in Critically Ill Patients at a Tertiary Care Medical Center

被引：188

作者：

Akajagbor, Darowan S. ^{[1
,2
,3
]}

Wilson, Sharon L. ^{[3
]}

Shere-Wolfe, Kapana D. ^{[5
]}

Dakum, Paul ^{[4
]}

Charurat, Manhattan E. ^{[4
]}

Gilliam, Bruce L. ^{[4
,5
]}

机构：

[1] DYouville Coll Sch Pharm, Dept Pharm Practice, Buffalo, NY USA

[2] Upstate Med Ctr, Dept Pharm Practice, Syracuse, NY USA

[3] Univ Maryland, Med Ctr, Dept Pharm Practice, Baltimore, MD 21201 USA

[4] Univ Maryland, Sch Med, Inst Human Virol, Baltimore, MD 21201 USA

[5] Univ Maryland, Sch Med, Div Infect Dis, Baltimore, MD 21201 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2013年 / 57卷 / 09期

关键词：

PB; colistin; colistimethate sodium; nephrotoxicity; AKI; GRAM-NEGATIVE BACTERIA; COLISTIN; NEPHROTOXICITY; INFECTIONS; THERAPY; DEFINITION;

D O I：

10.1093/cid/cit453

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Nephrotoxicity was assessed in 173 critically ill patients receiving intravenous colistin or polymyxin B; it occurred in 60.4% and 41.8%, respectively. Further investigation is necessary to elucidate the reason for the difference in nephrotoxicity observed between the groups and to assess the impact of severity of illness and dosing/administration.

引用

页码：1300 / 1303

页数：4

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