Colistin Dosing and Nephrotoxicity in a Large Community Teaching Hospital

被引：136

作者：

DeRyke, C. Andrew ^{[1
]}

Crawford, Amanda J. ^{[2
]}

Uddin, Nizam ^{[3
]}

Wallace, Mark R. ^{[4
]}

机构：

[1] Orlando Hlth, Orlando Reg Med Ctr, Dept Pharm, Orlando, FL 32806 USA

[2] Univ Florida, Dept Epidemiol & Biostat, Gainesville, FL USA

[3] Univ Cent Florida, Dept Stat, Orlando, FL 32816 USA

[4] Orlando Hlth, Div Infect Dis, Orlando, FL 32806 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 10期

关键词：

CRITICALLY-ILL PATIENTS; GRAM-NEGATIVE BACTERIA; INTRAVENOUS COLISTIN; MULTIDRUG-RESISTANT; INFECTIONS; METHANESULFONATE; THERAPY; PHARMACOKINETICS; CLASSIFICATION; TOXICITY;

D O I：

10.1128/AAC.01707-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Thirty adult patients who received intravenous colistin (5.1 +/- 2.4 mg/kg/day) were reviewed to evaluate dosing with respect to nephrotoxicity, which occurred in 10 (33%) patients within the first 5 days of treatment. Excessive colistin dosing was frequent (47%), often (71%) resulted from the use of actual body weight in obese patients, and was associated with higher rates of nephrotoxicity (80% versus 30%, P = 0.019).

引用

页码：4503 / 4505

页数：3

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