Antinociception of β-D-glucan from Pleurotus pulmonarius is possibly related to protein kinase C inhibition

被引：41

作者：

Baggio, Cristiane Hatsuko ^{[2
]}

Freitas, Cristina Setim ^{[2
]}

Marcon, Rodrigo ^{[3
]}

de Paula Werner, Maria Fernanda ^{[2
,3
]}

Rae, Giles Alexander ^{[3
]}

Smiderle, Fhernanda Ribeiro ^{[4
]}

Sassaki, Guilherme Lanzi ^{[4
]}

Iacomini, Marcello ^{[4
]}

Andrade Marques, Maria Consuelo ^{[2
]}

Soares Santos, Adair Roberto ^{[1
]}

机构：

[1] Univ Fed Santa Catarina, Lab Neurobiol Pain & Inflammat, Dept Physiol Sci, Ctr Biol Sci, BR-88040900 Florianopolis, SC, Brazil

[2] Univ Fed Parana, Sect Biol Sci, Dept Pharmacol, BR-80060000 Curitiba, Parana, Brazil

[3] Univ Fed Santa Catarina, Ctr Biol Sci, Dept Pharmacol, BR-88040900 Florianopolis, SC, Brazil

[4] Univ Fed Parana, Sect Biol Sci, Dept Biochem & Mol Biol, BR-80060000 Curitiba, Parana, Brazil

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2012年 / 50卷 / 03期

关键词：

beta-D-Glucan; Pleurotus pulmonarius; Nociception; TRP channels; PKC; SENSORY NEURONS; GLUTAMATE RELEASE; PAIN; ACTIVATION; TRPA1; MICE; NOCICEPTION; MECHANISMS; TRPV1; POLYSACCHARIDES;

D O I：

10.1016/j.ijbiomac.2011.10.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

beta-D-Glucan, a polysaccharide isolated from an edible mushroom Pleurotus pulmonarius (Fr.) Quel., presented antinociceptive activity in mice. This study evaluated the involvement of transient receptor potential (TRP) channels and protein kinase C (PKC) on antinociceptive effect of a (1 -> 3),(1 -> 6)-linked beta-D-glucan (GL) in mice. Intraperitoneal administration of GL potently inhibited nociceptive responses induced by intraplantar injections of capsaicin, cinnamaldehyde, menthol, acidified saline and phorbol myristate acetate (PMA). Moreover, Western blot analysis revealed that GL treatment also prevented PMA-induced PKC epsilon activation. Collectively, present results demonstrate that GL could constitute an attractive molecule of interest for the development of new analgesic drugs. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：872 / 877

页数：6

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