Protein degradation: Go outside and see the proteasome

被引:31
作者
Lord, JM
机构
[1] Department of Biological Sciences, University of Warwick
关键词
D O I
10.1016/S0960-9822(02)70666-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Newly synthesized proteins that fail to fold or assemble properly in the endoplasmic reticulum are degraded. Recent work on several endoplasmic reticulum membrane proteins has shown that the cytosolic proteasome plays a role in their degradation.
引用
收藏
页码:1067 / 1069
页数:3
相关论文
共 13 条
[1]   Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway [J].
Biederer, T ;
Volkwein, C ;
Sommer, T .
EMBO JOURNAL, 1996, 15 (09) :2069-2076
[2]  
Fra A, 1993, Subcell Biochem, V21, P143
[3]   QUALITY-CONTROL IN THE SECRETORY PATHWAY [J].
HAMMOND, C ;
HELENIUS, A .
CURRENT OPINION IN CELL BIOLOGY, 1995, 7 (04) :523-529
[4]   MULTIPLE PROTEOLYTIC SYSTEMS, INCLUDING THE PROTEASOME, CONTRIBUTE TO CFTR PROCESSING [J].
JENSEN, TJ ;
LOO, MA ;
PIND, S ;
WILLIAMS, DB ;
GOLDBERG, AL ;
RIORDAN, JR .
CELL, 1995, 83 (01) :129-135
[5]   PROTEIN-DEGRADATION IN THE ENDOPLASMIC-RETICULUM [J].
KLAUSNER, RD ;
SITIA, R .
CELL, 1990, 62 (04) :611-614
[6]   DEGRADATION FROM THE ENDOPLASMIC-RETICULUM - DISPOSING OF NEWLY SYNTHESIZED PROTEINS [J].
LIPPINCOTTSCHWARTZ, J ;
BONIFACINO, JS ;
YUAN, LC ;
KLAUSNER, RD .
CELL, 1988, 54 (02) :209-220
[7]   Assembly of ER-associated protein degradation in vitro: Dependence on cytosol, calnexin, and ATP [J].
McCracken, AA ;
Brodsky, JL .
JOURNAL OF CELL BIOLOGY, 1996, 132 (03) :291-298
[8]  
PELHAM H R B, 1992, Trends in Cell Biology, V2, P183, DOI 10.1016/0962-8924(92)90230-K
[9]   TRANSPORT OF PROTEINS ACROSS THE ENDOPLASMIC-RETICULUM MEMBRANE [J].
RAPOPORT, TA .
SCIENCE, 1992, 258 (5084) :931-936
[10]   DISTINCT PROCESSES MEDIATE GLYCOPROTEIN AND GLYCOPEPTIDE EXPORT FROM THE ENDOPLASMIC-RETICULUM IN SACCHAROMYCES-CEREVISIAE [J].
ROMISCH, K ;
SCHEKMAN, R .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (15) :7227-7231