Essential role of Drosophila Hdac1 in homeotic gene silencing

被引：51

作者：

Chang, YL ^{[1
]}

Peng, YH ^{[1
]}

Pan, IC ^{[1
]}

Sun, DS ^{[1
]}

King, B ^{[1
]}

Huang, DH ^{[1
]}

机构：

[1] Acad Sinica, Inst Mol Biol, Taipei 11529, Taiwan

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2001年 / 98卷 / 17期

关键词：

Pc-G; histone deacetylase; Ubx; PRE;

D O I：

10.1073/pnas.171325498

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Deacetylation of the N-terminal tails of core histones plays a crucial role in gene silencing. Rpd3 and Hda1 represent two major types of genes encoding trichostatin A-sensitive histone deacetylases. Although they have been widely found, their cellular and developmental roles remain to be elucidated in metazoa. We show that Drosophila Hdac1, an Rpd3-type gene, interacts cooperatively with Polycomb group repressors in silencing the homeotic genes that are essential for axial patterning of body segments. The biochemical copurification and cytological colocalization of HDAC1 and Polycomb group repressors strongly suggest that HDAC1 is a component of the silencing complex for chromatin modification on specific regulatory regions of homeotic genes.

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页码：9730 / 9735

页数：6

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