A novel bicyclic hexapeptide, RA-XVIII, from Rubia cordifolia:: Structure, semi-synthesis, and cytotoxicity

被引：34

作者：

Lee, Ji-Ean ^{[1
]}

Hitotsuyanagi, Yukio ^{[1
]}

Kim, Ik-Hwi ^{[1
]}

Hasuda, Tomoyo ^{[1
]}

Takeya, Koichi ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Tokyo 1920392, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 02期

关键词：

RA-XVIII; deoxybouvardin; cytotoxicity; Rubia cordifolia; synthesis;

D O I：

10.1016/j.bmcl.2007.11.030

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new bicyclic peptide of RA-series, RA-XVIII (3), was isolated from the roots of Rubio cordifolia L. Its structure was established to be a hydroxylated derivative of RA-VII by the semi-synthesis of 3 from deoxybouvardin, and its cytotoxicity against P-388 cells was 0.012 mu g/mL. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：808 / 811

页数：4

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