Regulation of hunger-driven behaviors by neural ribosomal S6 kinase in Drosophila

被引:194
作者
Wu, Q
Zhang, Y
Xu, J
Shen, P
机构
[1] Univ Georgia, Dept Cellular Biol, Athens, GA 30602 USA
[2] Univ Georgia, Biomed & Hlth Sci Inst, Athens, GA 30602 USA
关键词
Drosophila insulin-like peptide; feeding behavior; food preference; neuropeptide F; neuroendocrine;
D O I
10.1073/pnas.0501914102
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Hunger elicits diverse, yet coordinated, adaptive responses across species, but the underlying signaling mechanism remains poorly understood. Here, we report on the function and mechanism of the Drosophila insulin-like system in the central regulation of different hunger-driven behaviors. We found that overexpression of Drosophila insulin-like peptides (DILPs) in the nervous system of fasted larvae suppressed the hunger-driven increase of ingestion rate and intake of nonpreferred foods (e.g., a less accessible solid food). Moreover, up-regulation of Drosophila p70/S6 kinase activity in DILP neurons led to attenuated hunger response by fasted larvae, whereas its down-regulation triggered fed larvae to display motivated foraging and feeding. Finally, we provide evidence that neural regulation of food preference but not ingestion rate may involve direct signaling by DILPs to neurons expressing neuropeptide F receptor 1, a receptor for neuropeptide Y-like neuropeptide F. Our study reveals a prominent role of neural Drosophila p70/S6 kinase in the modulation of hunger response by insulin-like and neuropeptide Y-like signaling pathways.
引用
收藏
页码:13289 / 13294
页数:6
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