Glucose biosensor based on carbon nanotube epoxy composites

被引：65

作者：

Pérez, B ^{[1
]}

Pumera, M ^{[1
]}

del Valle, M ^{[1
]}

Merkoçi, A ^{[1
]}

Alegret, S ^{[1
]}

机构：

[1] Univ Autonoma Barcelona, Dept Quim, Grp Sensors & Biosensors, E-08193 Barcelona, Catalonia, Spain

来源：

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2005年 / 5卷 / 10期

关键词：

carbon nanotubes; glucose oxidase; biosensor; multi-wall carbon nanotubes; amperometric detection;

D O I：

10.1166/jnn.2005.400

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel glucose biosensor based on a rigid and renewable carbon nanotube (CNT) based biocomposite is reported. The biosensor was based on the immobilization of glucose oxidase (GOx) within the CNT epoxy-composite matrix prepared by dispersion of multi-wall CNT inside the epoxy resin. The use of CNT, as the conductive part of the composite, ensures better incorporation of enzyme into the epoxy matrix and faster electron transfer rates between the enzyme and the transducer. Experimental results show that the CNT epoxy composite biosensor (GOx-CNTEC) offers an excellent sensitivity, reliable calibration profile, and stable electrochemical properties together with significantly lower detection potential (+0.55 V) than GOx-graphite epoxy composites (+0.90 V; difference Delta E = 0.35 V). The results obtained favorably compare to those of a glucose biosensor based on a graphite epoxy composite (GOx-GEC).

引用

页码：1694 / 1698

页数：5

共 26 条

[1] Nanotubes from carbon [J].

Ajayan, PM .

CHEMICAL REVIEWS, 1999, 99 (07) :1787-1799

[2]

Alegret S, 2003, INTEGRATED ANAL SYST, P377

[3] Recent developments in faradaic bioelectrochemistry [J].

Armstrong, FA ;

Wilson, GS .

ELECTROCHIMICA ACTA, 2000, 45 (15-16) :2623-2645

[4] Carbon nanotubes - the route toward applications [J].

Baughman, RH ;

Zakhidov, AA ;

de Heer, WA .

SCIENCE, 2002, 297 (5582) :787-792

[5] DIRECT ELECTRICAL COMMUNICATION BETWEEN CHEMICALLY MODIFIED ENZYMES AND METAL-ELECTRODES .1. ELECTRON-TRANSFER FROM GLUCOSE-OXIDASE TO METAL-ELECTRODES VIA ELECTRON RELAYS, BOUND COVALENTLY TO THE ENZYME [J].

DEGANI, Y ;

HELLER, A .

JOURNAL OF PHYSICAL CHEMISTRY, 1987, 91 (06) :1285-1289

[6] Glucose sensors based on glucose-oxidase-containing polypyrrole/aligned carbon nanotube coaxial nanowire electrodes [J].

Gao, M ;

Dai, L ;

Wallace, GG .

SYNTHETIC METALS, 2003, 137 (1-3) :1393-1394

[7] Carbon nanotube aqueous sol-gel composites: enzyme-friendly platforms for the development of stable biosensors [J].

Gavalas, VG ;

Law, SA ;

Ball, JC ;

Andrews, R ;

Bachas, LG .

ANALYTICAL BIOCHEMISTRY, 2004, 329 (02) :247-252

[8] ELECTRICAL CONNECTION OF ENZYME REDOX CENTERS TO ELECTRODES [J].

HELLER, A .

JOURNAL OF PHYSICAL CHEMISTRY, 1992, 96 (09) :3579-3587

[9] HELICAL MICROTUBULES OF GRAPHITIC CARBON [J].

IIJIMA, S .

NATURE, 1991, 354 (6348) :56-58

[10] A disposable biosensor for organophosphorus nerve agents based on carbon nanotubes modified thick film strip electrode [J].

Joshi, KA ;

Tang, J ;

Haddon, R ;

Wang, J ;

Chen, W ;

Mulchandani, A .

ELECTROANALYSIS, 2005, 17 (01) :54-58

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