Analysis of the oxidative stress response of Penicillium chrysogenum to menadione

被引：75

作者：

Emri, T ^{[1
]}

Pócsi, I ^{[1
]}

Szentirmai, A ^{[1
]}

机构：

[1] Lajos Kossuth Univ, Dept Microbiol & Biotechnol, H-4010 Debrecen, Hungary

来源：

FREE RADICAL RESEARCH | 1999年 / 30卷 / 02期

基金：

匈牙利科学研究基金会;

关键词：

oxidative stress; menadione; superoxide dismutase; glutathione; glucose-6-phosphate dehydrogenase; Penicillium chrysogenum;

D O I：

10.1080/10715769900300131

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The intracellular superoxide and glutathione disulphide concentrations increased in Penicillium chrysogeum treated with 50, 250 or 500 mu M menadione (MQ). A significant increase in the intracellular peroxide concentration was also observed when mycelia were exposed to 250 or 500 mu M MQ. The specific activity of Cu,Zn and Mn superoxide dismutases, glutathione reductase and glutathione S-transferase as well as the glutathione producing activity increased in the presence of MQ while glutathione peroxidase and gamma-glutamyltranspeptidase were only induced by high intracellular peroxide levels. The glucose-6-phosphate dehydrogenase and catalase activities did not respond to the oxidative stress caused by MQ.

引用

页码：125 / 132

页数：8

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