Palladium-catalyzed sp3 C-H activation of simple alkyl groups:: Direct preparation of indoline derivatives from N-alkyl-2-bromoanilines

被引：170

作者：

Watanabe, Toshiaki ^{[1
]}

Oishi, Shinya ^{[1
]}

Fujii, Nobutaka ^{[1
]}

Ohno, Hiroaki ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 09期

关键词：

D O I：

10.1021/ol800425z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The sp(3) C-H activation of a simple alkyl group catalyzed by palladium(0) provides a novel and convenient strategy for the synthesis of various indolines from simple precursors, such as N-alkyl-2-bromoanilines. This study demonstrates that assisting moieties in the substrate such as a pyridine or quaternary carbon are not always necessary for sp(3) C-H activation.

引用

页码：1759 / 1762

页数：4

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