Xenobiotic Metabolomics: Major Impact on the Metabolome

被引：189

作者：

Johnson, Caroline H. ^{[1
]}

Patterson, Andrew D. ^{[2
,3
]}

Idle, Jeffrey R. ^{[4
]}

Gonzalez, Frank J. ^{[1
]}

机构：

[1] NCI, Lab Metab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

[2] Penn State Univ, Dept Vet & Biomed Sci, University Pk, PA 16802 USA

[3] Penn State Univ, Ctr Mol Toxicol & Carcinogenesis, University Pk, PA 16802 USA

[4] Univ Bern, Dept Clin Res, Hepatol Res Grp, CH-3010 Bern, Switzerland

来源：

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 52 | 2012年 / 52卷

关键词：

pharmacometabolomics; gut microflora; interindividual variation; metabotype; UPLC; mass spectrometry; PREGNANE-X-RECEPTOR; SPECTROMETRY-BASED METABOLOMICS; QTOFMS-BASED METABOLOMICS; FLIGHT MASS-SPECTROMETRY; GAMMA-IRRADIATED RATS; HUMAN DRUG-METABOLISM; ST-JOHNS-WORT; MOUSE MODEL; INTESTINAL MICROBIOTA; GAS-CHROMATOGRAPHY;

D O I：

10.1146/annurev-pharmtox-010611-134748

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Xenobiotics are encountered by humans on a daily basis and include drugs, environmental pollutants, cosmetics, and even components of the diet. These chemicals undergo metabolism and detoxication to produce numerous metabolites, some of which have the potential to cause unintended effects such as toxicity. They can also block the action of enzymes or receptors used for endogenous metabolism or affect the efficacy and/or bioavailability of a coadministered drug. Therefore, it is essential to determine the full metabolic effects that these chemicals have on the body. Metabolomics, the comprehensive analysis of small molecules in a biofluid, can reveal biologically relevant perturbations that result from xenobiotic exposure. This review discusses the impact that genetic, environmental, and gut microflora variation has on the metabolome, and how these variables may interact, positively and negatively, with xenobiotic metabolism.

引用

页码：37 / 56

页数：20

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