Mechanisms of bone metastasis in prostate cancer: clinical implications

被引：108

作者：

Msaouel, Pavlos

Pissimissis, Nikos ^{[1
]}

Halapas, Antonios

Koutsilieris, Michael ^{[1
]}

机构：

[1] Natl & Kapodistrian Univ Athens, Sch Med, Dept Physiol, Goudi 11527, Greece

来源：

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2008年 / 22卷 / 02期

关键词：

bone metastasis; cancer therapy; micrometastasis; prostate cancer; survival factors;

D O I：

10.1016/j.beem.2008.01.011

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Prostate cancer shows a strong predilection to spread to the bones. Once prostate tumour cells are engrafted in the skeleton, curative therapy is no longer possible and palliative treatment becomes the only option. Herein, we review the multifactorial mechanisms and complex cellular interactions that take place inside the bone metastatic microenvironment. Emphasis is given to the detection and treatment of the micrometastatic stage of prostate cancer, as well as our recent attempts to target the bone metastasis microenvironment-related survival factors using an anti-survival factor manipulation which can increase the efficacy of anticancer therapies such as androgen ablation therapy and chemotherapy in advanced prostate cancer.

引用

页码：341 / 355

页数：15

共 76 条

[1]

Recent advances in the detection of bone marrow micrometastases: A promising area for research or just another false hope? A review of the literature [J].