10-Helical conformations in oxetane β-amino acid hexamers

被引：119

作者：

Claridge, TDW

Goodman, JM

Moreno, A

Angus, D

Barker, SF

Taillefumier, C

Watterson, MP

Fleet, GWJ

机构：

[1] Univ Oxford, Dyson Perrins Lab, Oxford OX1 3QY, England

[2] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 25期

基金：

英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/S0040-4039(01)00661-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first structural investigations were undertaken on a P-hexapeptide 7 in which the peptide backbone is constrained by cis-substituted oxetane rings. Detailed NMR studies in CDCl3 and C6D6 together with molecular mechanics conformational analysis identify a well-defined left-handed helical structure stabilised by 10-membered hydrogen-bonded rings. Comparison with two related hexapeptides 8 and 9 suggests a similar structural preference for these systems. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：4251 / 4255

页数：5

共 30 条

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