Chronic hyperammonemia alters motor and neurochemical responses to activation of group I metabotropic glutamate receptors in the nucleus accumbens in rats in vivo

被引：39

作者：

Canales, JJ ^{[1
]}

Elayadi, A ^{[1
]}

Errami, M ^{[1
]}

Llansola, M ^{[1
]}

Cauli, O ^{[1
]}

Felipo, V ^{[1
]}

机构：

[1] Inst Invest Citological Caja Ahorros Valencia, Neurobiol Lab, Fundac Valenciana Invest Biomed, Valencia 46010, Spain

来源：

NEUROBIOLOGY OF DISEASE | 2003年 / 14卷 / 03期

关键词：

ammonia; hepatic encephalopathy; motor behavior; dopamine; glutamate;

D O I：

10.1016/j.nbd.2003.08.023

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Hyperammonemia leads to altered cerebral function and neurological alterations in patients with hepatic encephalopathy. We studied the effects of hyperammonemia in rats on the modulation by group I metabotropic glutamate receptors (mGluR) of motor and neurochemical functions in vivo. Locomotion induced by injection of the mGluR agonist DHPG into nucleus accumbens was increased in hyperammonemic rats. In control rats DHPG increased extracellular dopamine (ca. 400%) but not glutamate. In contrast, in hyperammonemic rats DHPG increased extracellular glutamate (ca. 600%), while DHPG-induced dopamine increase was reduced. Blocking mGluR1 receptor with CPCCOEt prevented all DHPG effects, indicating that this receptor mediates its locomotor and neurochemical effects. Hyperammonemic rats showed increased (32%) mGluR1 a, but not mGluR5 content in nucleus accumbens. These results show that modulation of locomotor and neurochemical functions by mGluRs in nucleus accumbens is strongly altered in hyperammonemia. These alterations may contribute to the neurological alterations in hyperammonemia and liver failure. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：380 / 390

页数：11

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