SIGNAL TRANSDUCTION How cells sense energy

被引:23
作者
Hardie, D. Grahame [1 ]
机构
[1] Univ Dundee, Coll Life Sci, Dundee DD1 5EH, Scotland
关键词
ACTIVATED PROTEIN-KINASE; BINDING;
D O I
10.1038/472176a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];
摘要
Maintaining an optimal cellular energy status requires sensing the levels of the adenine nucleotides ATP, ADP and AMP. Biochemical and structural studies of the enzyme AMPK provide insights into how this is achieved. See Letter p.230
引用
收藏
页码:176 / 177
页数:2
相关论文
共 10 条
[1]
PURIFICATION AND CHARACTERIZATION OF THE AMP-ACTIVATED PROTEIN-KINASE - COPURIFICATION OF ACETYL-COA CARBOXYLASE KINASE AND 3-HYDROXY-3-METHYLGLUTARYL-COA REDUCTASE KINASE-ACTIVITIES [J].
CARLING, D ;
CLARKE, PR ;
ZAMMIT, VA ;
HARDIE, DG .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1989, 186 (1-2) :129-136
[2]
Structural insight into the autoinhibition mechanism of AMP-activated protein kinase [J].
Chen, Lei ;
Jiao, Zhi-Hao ;
Zheng, Li-Sha ;
Zhang, Yuan-Yuan ;
Xie, Shu-Tao ;
Wang, Zhi-Xin ;
Wu, Jia-Wei .
NATURE, 2009, 459 (7250) :1146-U139
[3]
5'-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2A(c) [J].
Davies, SP ;
Helps, NR ;
Cohen, PTW ;
Hardie, DG .
FEBS LETTERS, 1995, 377 (03) :421-425
[4]
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy [J].
Hardie, D. Grahame .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2007, 8 (10) :774-785
[5]
5'-AMP ACTIVATES THE AMP-ACTIVATED PROTEIN-KINASE CASCADE AND CA2+/CALMODULIN ACTIVATES THE CALMODULIN-DEPENDENT PROTEIN-KINASE-I CASCADE, VIA 3 INDEPENDENT MECHANISMS [J].
HAWLEY, SA ;
SELBERT, MA ;
GOLDSTEIN, EG ;
EDELMAN, AM ;
CARLING, D ;
HARDIE, DG .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (45) :27186-27191
[6]
β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK) [J].
Oakhill, Jonathan S. ;
Chen, Zhi-Ping ;
Scott, John W. ;
Steel, Rohan ;
Castelli, Laura A. ;
Ling, Naomi ;
Macaulay, S. Lance ;
Kemp, Bruce E. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (45) :19237-19241
[7]
CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations [J].
Scott, JW ;
Hawley, SA ;
Green, KA ;
Anis, M ;
Stewart, G ;
Scullion, GA ;
Norman, DG ;
Hardie, DG .
JOURNAL OF CLINICAL INVESTIGATION, 2004, 113 (02) :274-284
[8]
Dissecting the role of 5′-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase [J].
Suter, Marianne ;
Riek, Uwe ;
Tuerk, Roland ;
Schlattner, Uwe ;
Wallimann, Theo ;
Neumann, Dietbert .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (43) :32207-32216
[9]
Structural basis for AMP binding to mammalian AMP-activated protein kinase [J].
Xiao, Bing ;
Heath, Richard ;
Saiu, Peter ;
Leiper, Fiona C. ;
Leone, Philippe ;
Jing, Chun ;
Walker, Philip A. ;
Haire, Lesley ;
Eccleston, John F. ;
Davis, Colin T. ;
Martin, Stephen R. ;
Carling, David ;
Gamblin, Steven J. .
NATURE, 2007, 449 (7161) :496-U14
[10]
Structure of mammalian AMPK and its regulation by ADP [J].
Xiao, Bing ;
Sanders, Matthew J. ;
Underwood, Elizabeth ;
Heath, Richard ;
Mayer, Faith V. ;
Carmena, David ;
Jing, Chun ;
Walker, Philip A. ;
Eccleston, John F. ;
Haire, Lesley F. ;
Saiu, Peter ;
Howell, Steven A. ;
Aasland, Rein ;
Martin, Stephen R. ;
Carling, David ;
Gamblin, Steven J. .
NATURE, 2011, 472 (7342) :230-233