Gut microbiome analysis in neuromyelitis optica reveals overabundance of Clostridium perfringens

被引：148

作者：

Cree, Bruce A. C. ^{[1
]}

Spencer, Collin M. ^{[1
,2
]}

Varrin-Doyer, Michel ^{[1
,2
,3
]}

Baranzini, Sergio E. ^{[1
]}

Zamvil, Scott S. ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Dept Neurol, 675 Nelson Rising Lane,NS-215A, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Program Immunol, 675 Nelson Rising Lane,NS-215A, San Francisco, CA 94158 USA

[3] Novartis AG, Basel, Switzerland

来源：

ANNALS OF NEUROLOGY | 2016年 / 80卷 / 03期

关键词：

REGULATORY T-CELLS; INDUCTION;

D O I：

10.1002/ana.24718

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

T cells from neuromyelitis optica (NMO) patients, which recognize the immunodominant epitope of aquaporin-4, exhibit Th17 polarization and cross-react with a homologous sequence of a Clostridium perfringens adenosine triphosphate-binding cassette transporter. Therefore, this commensal microbe might participate in NMO pathogenesis. We examined the gut microbiome by PhyloChip G3 from 16 NMO patients, 16 healthy controls (HC), and 16 multiple sclerosis patients. A significant difference in the abundance of several microbial communities was observed between NMO and HC (Adonis test, p=0.001). Strikingly, C. perfringens was overrepresented in NMO (p=5.24x10(-8)). These observations support a potential role for C. perfringens in NMO pathogenesis. Ann Neurol 2016;80:443-447

引用

页码：443 / 447

页数：5

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