Chemokines: established and novel targets in atherosclerosis

被引：85

作者：

Koenen, Rory R. ^{[1
,2
]}

Weber, Christian ^{[1
,2
,3
]}

机构：

[1] Univ Munich, Inst Cardiovasc Prevent, Munich, Germany

[2] Maastricht Univ, Cardiovasc Res Inst Maastricht CARIM, Maastricht, Netherlands

[3] Munich Heart Alliance, Munich, Germany

来源：

EMBO MOLECULAR MEDICINE | 2011年 / 3卷 / 12期

关键词：

atherosclerosis; chemokine; inflammation; leukocyte; therapeutic; REGULATORY T-CELLS; BONE-MARROW; MONOCLONAL-ANTIBODY; NEOINTIMA FORMATION; BINDING-PROTEIN; MACROPHAGE ACCUMULATION; MONOCYTE SUBSETS; PLAQUE-FORMATION; DENDRITIC CELLS; MICE REVEALS;

D O I：

10.1002/emmm.201100183

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In their role as small chemotactic cytokines, chemokines are crucial mediators and regulators of leukocyte trafficking during immune surveillance and inflammation. Their involvement in the development and progression of inflammatory diseases has been subject of intense investigation. Concordantly, the chemokine system has been explored in search for therapeutic targets to prevent or treat inflammatory disorders, such as atherosclerosis. Targeting the chemokine system offers various entry points for a causative treatment of this widespread and chronic illness. Although this approach has encountered some setbacks, several innovative compounds are currently in an advanced stage of development. In this review, the current standing of this dynamic field is highlighted and the potential advantages and drawbacks of particular strategies are discussed.

引用

页码：713 / 725

页数：13

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