Depression: from psychopathology to pathophysiology

被引：128

作者：

Belzung, Catherine ^{[1
,2
]}

Willner, Paul ^{[3
]}

Philippot, Pierre ^{[4
]}

机构：

[1] INSERM 930, F-37300 Tours, France

[2] Univ Tours, F-37300 Tours, France

[3] Swansea Univ, Dept Psychol, Swansea SA2 8PP, W Glam, Wales

[4] Catholic Univ Louvain, Dept Psychol, B-1348 Louvain La Neuve, Belgium

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2015年 / 30卷

关键词：

ADULT HIPPOCAMPAL NEUROGENESIS; DEFAULT MODE NETWORK; MAJOR DEPRESSION; IMPAIRED DISENGAGEMENT; FACIAL EXPRESSIONS; AMYGDALA RESPONSES; EMOTION REGULATION; PREFRONTAL CORTEX; NEURAL RESPONSE; COGNITIVE MODEL;

D O I：

10.1016/j.conb.2014.08.013

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Major depression is a psychiatric disorder with high prevalence. Both specialists in cognitive psychopathology and neurobiologists have proposed explanations of the process/systems that exhibit altered functioning during this disorder. Psychological processes that are dysfunctional in depressed patients include alterations in self-referential schemas, cognitive biases, ruminations and processing mode (overgeneral versus concrete). These cognitive processes are associated with altered function of specific brain systems, including prefrontal areas and cingulate cortex (both involved in self-referential processes and rumination), amygdala (cognitive bias), lateral habenula (cognitive bias) and hippocampus (cognitive bias and overgeneral processing). This review aims to present a coherent view integrating these two approaches in a unique model.

引用

页码：24 / 30

页数：7

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