microRNAs as Regulators of Adipogenic Differentiation of Mesenchymal Stem Cells

被引：72

作者：

Hamam, Dana ^{[1
]}

Ali, Dalia ^{[1
]}

Kassem, Moustapha ^{[1
,2
]}

Aldahmash, Abdullah ^{[1
,2
]}

Alajez, Nehad M. ^{[1
]}

机构：

[1] King Saud Univ, Coll Med, Dept Anat, Stem Cell Unit, Riyadh 11461, Saudi Arabia

[2] Univ Southern Denmark, Dept Endocrinol, KMEB, Odense, Denmark

来源：

STEM CELLS AND DEVELOPMENT | 2015年 / 24卷 / 04期

关键词：

3T3-L1 ADIPOCYTE DIFFERENTIATION; MULTIPOTENT STROMAL CELLS; SMALL HETERODIMER PARTNER; ORPHAN NUCLEAR RECEPTOR; HUMAN ADIPOSE-TISSUE; BONE-MARROW; PPAR-GAMMA; TRANSCRIPTIONAL REGULATION; OSTEOBLAST DIFFERENTIATION; NEGATIVE REGULATOR;

D O I：

10.1089/scd.2014.0331

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

microRNAs (miRNAs) constitute complex regulatory network, fine tuning the expression of a myriad of genes involved in different biological and physiological processes, including stem cell differentiation. Mesenchymal stem cells (MSCs) are multipotent stem cells present in the bone marrow stroma, and the stroma of many other tissues, and can give rise to a number of mesoderm-type cells including adipocytes and osteoblasts, which form medullary fat and bone tissues, respectively. The role of bone marrow fat in bone mass homeostasis is an area of intensive investigation with the aim of developing novel approaches for enhancing osteoblastic bone formation through inhibition of bone marrow fat formation. A number of recent studies have reported several miRNAs that enhance or inhibit adipogenic differentiation of MSCs and with potential use in microRNA-based therapy to regulate adipogenesis in the context of treating bone diseases and metabolic disorders. The current review focuses on miRNAs and their role in regulating adipogenic differentiation of MSCs.

引用

页码：417 / 425

页数：9

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