Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing

被引:228
作者
Harikrishnan, KN
Chow, MZ
Baker, EK
Pal, S
Bassal, S
Brasacchio, D
Wang, L
Craig, JM
Jones, PL
Sif, S
El-Osta, A
机构
[1] Baker Med Res Inst, Alfred Med Res & Educ Precinct, Epigenet Human Hlth & Dis Lab, Prahran, Vic 3181, Australia
[2] Ohio State Univ, Dept Mol & Cellular Biochem, Columbus, OH 43210 USA
[3] Royal Childrens Hosp, Murdoch Childrens Res Inst, Melbourne, Vic, Australia
[4] Univ Illinois, Dept Cell & Struct Biol, Urbana, IL 61802 USA
基金
英国医学研究理事会;
关键词
D O I
10.1038/ng1516
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Transcriptional repression of methylated genes can be mediated by the methyl-CpG binding protein MeCP2. Here we show that human Brahma (Brm), a catalytic component of the SWI/SNF-related chromatin-remodeling complex, associates with MeCP2 in vivo and is functionally linked with repression. We used a number of different molecular approaches and chromatin immunoprecipitation strategies to show a unique cooperation between Brm, BAF57 and MeCP2. We show that Brm and MeCP2 assembly on chromatin occurs on methylated genes in cancer and the gene FMR1 in fragile X syndrome. These experimental findings identify a new role for SWI/SNF in gene repression by MeCP2.
引用
收藏
页码:254 / 264
页数:11
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