TRbase: a database relating tandem repeats to disease genes for the human genome

被引：37

作者：

Boby, T ^{[1
]}

Patch, AM ^{[1
]}

Aves, SJ ^{[1
]}

机构：

[1] Univ Exeter, Sch Biol & Chem Sci, Washington Singer Labs, Exeter EX4 4QG, Devon, England

来源：

BIOINFORMATICS | 2005年 / 21卷 / 06期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1093/bioinformatics/bti059

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Motivation: Tandem repeats are associated with disease genes, play an important role in evolution and are important in genomic organization and function. Although much research has been done on short perfect patterns of repeats, there has been less focus on imperfect repeats. Thus, there is an acute need for a tandem repeats database that provides reliable and up to date information on both perfect and imperfect tandem repeats in the human genome and relates these to disease genes. Results: This paper presents a web-accessible relational tandem repeats database that relates tandem repeats to gene locations and disease genes of the human genome. In contrast to other available databases, this database identifies both perfect and imperfect repeats of 1-2000 bp unit lengths. The utility of this database has been illustrated by analysing these repeats for their distribution and frequencies across chromosomes and genomic locations and between protein-coding and non-coding regions. The applicability of this database to identify diseases associated with previously uncharacterized tandem repeats is demonstrated.

引用

页码：811 / 816

页数：6

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