Evolution of helical foldamers

被引：118

作者：

Sanford, AR ^{[1
]}

Gong, B ^{[1
]}

机构：

[1] SUNY Buffalo, Dept Chem, Buffalo, NY 14260 USA

来源：

CURRENT ORGANIC CHEMISTRY | 2003年 / 7卷 / 16期

关键词：

DE-NOVO DESIGN; NMR-SOLUTION STRUCTURE; AROMATIC SIDE-CHAINS; BETA-PEPTIDES; SECONDARY STRUCTURE; SELF-ORGANIZATION; PEPTOID OLIGOMERS; AQUEOUS-SOLUTION; LIGAND STRANDS; GAMMA-PEPTIDES;

D O I：

10.2174/1385272033486260

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The overwhelming majority of unnatural foldamers described so far adopt various helical conformations. Helical foldamers include peptidomimetic oligomers such alpha-, beta- and gamma-peptides, and non-biological helices such as helicates, oligoheterocycles and olio(phenylene ethynylenes). Lying between peptidoinitnetic and non-biological foldamers are oligoarylamides whose backbones are rigidified by strong intramolecular hydrogen bonds. The localized nature of the intramolecular hydrogen bonds allows Structure the tuning of both the side chains and the curvature of the backbones, leading to helices of different surface properties and tunable interior cavities. As a result, hollow helices with interior channels Of tunable, finite diameters are generated. Thus, unnatural helical foldamers have evolved front providing examples of stably folded secondary structures to demonstrating features of higher structural levels of biomacromolecules, e.g., the creation of nanocavities.

引用

页码：1649 / 1659

页数：11

共 101 条

[31] Foldamers: A manifesto [J].