A specific and sensitive method for detection of hypochlorous acid for the imaging of microbe-induced HOCl production

被引：228

作者：

Chen, Xiaoqiang ^{[3
]}

Lee, Kyung-Ah ^{[1
,2
]}

Ha, Eun-Mi ^{[4
]}

Lee, Kyung Mi ^{[3
,5
]}

Seo, You Yeong ^{[6
,7
]}

Choi, Han Kyoung ^{[6
,7
]}

Kim, Ha Na ^{[3
]}

Kim, Min Jung ^{[3
]}

Cho, Chun-Seok ^{[6
,7
]}

Lee, Soo Young ^{[5
,6
,7
]}

Lee, Won-Jae ^{[1
,2
]}

Yoon, Juyoung ^{[3
,5
]}

机构：

[1] Seoul Natl Univ, Sch Biol Sci, Seoul 51742, South Korea

[2] Seoul Natl Univ, Natl Creat Res Initiat Ctr Symbiosyst, Seoul 51742, South Korea

[3] Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 120750, South Korea

[4] Catholic Univ Daegu, Coll Pharm, Taegu 712702, South Korea

[5] Ewha Womans Univ, Dept Bioinspired Sci, Seoul 120750, South Korea

[6] Ewha Womans Univ, Dept Life Sci, Seoul 120750, South Korea

[7] Ewha Womans Univ, Div Life & Pharmaceut Sci, Seoul 120750, South Korea

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 15期

关键词：

DROSOPHILA GUT IMMUNITY; FLUORESCENT-PROBE; NEUTROPHIL PHAGOSOME; HYDROGEN-PEROXIDE; LIVING CELLS; DUAL OXIDASE; MYELOPEROXIDASE; ATHEROSCLEROSIS; MACROPHAGES; HOMEOSTASIS;

D O I：

10.1039/c1cc10589b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A specific and sensitive fluorescence-based method was developed for the imaging of microbe-induced HOCl production. Furthermore, we demonstrate dual oxidase (DUOX)-mediated HOCl generation in the mucosa of live animals providing a novel insight into mucosal innate immunity.

引用

页码：4373 / 4375

页数：3

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