Dual oxidase in mucosal immunity and host-microbe homeostasis

被引：174

作者：

Bae, Yun Soo ^{[1
]}

Choi, Myoung Kwon ^{[1
,2
]}

Lee, Won-Jae ^{[1
,2
]}

机构：

[1] Ewha Womans Univ, Div Life & Pharmaceut Sci, Dept Life Sci, Dept Bioinspired Sci, Seoul 120750, South Korea

[2] Natl Creat Res Initiat Ctr Symbiosyst, Seoul 120750, South Korea

来源：

TRENDS IN IMMUNOLOGY | 2010年 / 31卷 / 07期

关键词：

FAMILY NADPH OXIDASES; HYDROGEN-PEROXIDE; NEUTROPHIL PHAGOSOME; BACTERIAL; INNATE; SYSTEM; NOX; ACTIVATION; DEFENSE; DUOX;

D O I：

10.1016/j.it.2010.05.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mucosal epithelia are in direct contact with microbes, which range from beneficial symbionts to pathogens. Accordingly, hosts must have a conflicting strategy to combat pathogens efficiently while tolerating symbionts. Recent progress has revealed that dual oxidase (DUOX) plays a key role in mucosal immunity in organisms that range from flies to humans. Information from the genetic model of Drosophila has advanced our understanding of the regulatory mechanism of DUOX and its role in mucosa! immunity. Further investigations of DUOX regulation in response to symbiotic or non-symbiotic bacteria and the in vivo consequences in host physiology will give a novel insight into the microbe-controlling system of the mucosa.

引用

收藏

页码：278 / 287

页数：10

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