Estrogenic activity of a polyphenolic extract of the leaves of Epimedium brevicornum

被引：17

作者：

De Naeyer, A

Pocock, V

Milligan, S

De Keukeleire, D

机构：

[1] Univ Ghent, Fac Pharmaceut Sci, Lab Pharmacognosy & Phytochem, B-9000 Ghent, Belgium

[2] Kings Coll London, Sch Biomed Sci, Endocrinol & Reprod Res Grp, London SE1 1UL, England

来源：

FITOTERAPIA | 2005年 / 76卷 / 01期

关键词：

Epimedium brevicornum; estrogenic activity; yeast cell assay; Ishikawa Var-1 assay;

D O I：

10.1016/j.fitote.2004.10.002

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The estrogenic activity of a polyphenolic extract of the leaves of Epimedium brevicornum and five fractions obtained by solid-phase extraction were investigated using estrogen-responsive bioassays, a yeast cell assay and the Ishikawa Var-I assay. The extract was found to exhibit significant estrogenic activity in both assays. Furthermore, bioassay-guided fractionation led to localisation of the estrogenicity in the relatively non-polar fractions of the polyphenolic extract. (C) 2004 Elsevier B.V. All rights reserved.

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收藏

页码：35 / 40

页数：6

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