Brain derived neurotrophic factor gene polymorphism (Val66Met) and short-term antidepressant response in major depressive disorder

被引：44

作者：

Chi, Mei Hung ^{[1
]}

Chang, Hui Hua ^{[2
]}

Lee, Sheng-Yu ^{[1
]}

Lee, I. Hui ^{[1
]}

Gean, Po Wu ^{[3
]}

Yang, Yen Kuang ^{[1
]}

Lu, Ru-Band ^{[1
,4
]}

Chen, Po See ^{[1
]}

机构：

[1] Natl Cheng Kung Univ, Dept Psychiat, Hosp & Coll Med, Tainan 70428, Taiwan

[2] Natl Cheng Kung Univ, Inst Biopharmaceut Sci, Hosp & Coll Med, Tainan 70428, Taiwan

[3] Natl Cheng Kung Univ, Dept Pharmacol, Hosp & Coll Med, Tainan 70428, Taiwan

[4] Natl Cheng Kung Univ, Inst Behav Med, Hosp & Coll Med, Tainan 70428, Taiwan

来源：

JOURNAL OF AFFECTIVE DISORDERS | 2010年 / 126卷 / 03期

关键词：

Antidepressant; Brain derived neurotrophic factor; Major depressive disorder; Single nucleotide polymorphism; PROPHYLACTIC LITHIUM RESPONSE; BDNF GENE; ASSOCIATION; ESCITALOPRAM; VENLAFAXINE; SEROTONIN;

D O I：

10.1016/j.jad.2010.07.006

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Backgrounds: To determine the association between the brain derived neurotrophic factor (BDNF) Val66Met polymorphism and short-term antidepressant response in Taiwanese patients with major depressive disorder (MDD). Methods: We recruited 117 MDD patients who were randomized to fluoxetine or venlafaxine treatment and 106 controls. The association between genotypes and percentage changes in the Hamilton Rating Scale for Depression (HAM-D) scores over time was analyzed by repeated-measures ANOVA. The antidepressants were included in the model as covariates. Results: The frequency of the BDNF Val66Met polymorphisms was not significantly different between patient and control groups. Significantly changes in HAM-D scores were noted after 2 and 4 weeks of venlafaxine treatment among different genotypes. Conclusions: Results suggest antidepressants acting through different mechanisms may affect the BDNF Val66Met polymorphism differently. (C) 2010 Elsevier B.V. All rights reserved.

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页码：430 / 435

页数：6

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