Pregabalin: Its pharmacology and use in pain management

被引：253

作者：

Gajraj, Noor M. ^{[1
]}

机构：

[1] Texas Anodyne Res Inst, Sherman Pain care, Sherman, TX USA

来源：

ANESTHESIA AND ANALGESIA | 2007年 / 105卷 / 06期

关键词：

D O I：

10.1213/01.ane.0000287643.13410.5e

中图分类号：

R614 [麻醉学];

学科分类号：

100217 [麻醉学];

摘要：

Pregabalin is a new synthetic molecule and a structural derivative of the inhibitory neurotransmitter gamma-aminobutyric acid. It is an alpha(2)-delta (alpha(2)-delta) ligand that has analgesic, anticonvulsant, anxiolytic, and sleep-modulating activities. Pregabalin binds potently to the alpha(2)-delta subunit of calcium channels, resulting in a reduction in the release of several neurotransmitters, including glutamate, noradrenaline, serotonin, dopamine, and substance P. In this review, I will discuss the pharmacology of pregabalin and available efficacy studies in pain management. This review will focus on the advances in pregabalin pharmacology since my previous review in 2005.

引用

页码：1805 / 1815

页数：11

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