Biliary bile acids in hepatobiliary injury - What is the link?

被引：144

作者：

Fickert, Peter ^{[1
]}

Wagner, Martin ^{[1
]}

机构：

[1] Med Univ Graz, Dept Gastroenterol & Hepatol, Auenbruggerpl 15, A-8010 Graz, Austria

来源：

JOURNAL OF HEPATOLOGY | 2017年 / 67卷 / 03期

关键词：

Bile ducts; Bile canaliculus; Bile secretion; Cholangitis; Cholangiopathies; Primary biliary cholangitis; Primary sclerosing cholangitis; FAMILIAL INTRAHEPATIC CHOLESTASIS; SALT EXPORT PUMP; PRIMARY SCLEROSING CHOLANGITIS; P-GLYCOPROTEIN GENE; HEPATIC STELLATE CELLS; CYTOCHROME-C RELEASE; DUCT-LIGATED MICE; KNOCKOUT MICE; URSODEOXYCHOLIC ACID; LIVER-DISEASE;

D O I：

10.1016/j.jhep.2017.04.026

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

The main trigger for liver injury in acquired cholestatic liver disease remains unclear. However, the accumulation of bile acids (BAs) undoubtedly plays a role. Recent progress in deciphering the pathomechanisms of inborn cholestatic liver diseases, decoding mechanisms of BA-induced cell death, and generating modern BA-derived drugs has improved the understanding of the regulation of BA synthesis and transport. Now is the appropriate time to reassess current knowledge about the specific role of BAs in hepatobiliary injury. (C) 2017 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

引用

收藏

页码：619 / 631

页数：13

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