Mycophenolate mofetil, Cellcept®, a new immunosuppressive drug with great potential in internal medicine

被引：17

作者：

Gregoor, PJHS ^{[1
]}

van Gelder, T ^{[1
]}

Weimar, W ^{[1
]}

机构：

[1] Univ Hosp Rotterdam Dijkzigt, Dept Internal Med, NL-3000 CA Rotterdam, Netherlands

来源：

NETHERLANDS JOURNAL OF MEDICINE | 2000年 / 57卷 / 06期

关键词：

mycophenolate mofetil; kidney transplantation; auto-immune disease;

D O I：

10.1016/S0300-2977(00)00069-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mycophenolate mofetil is a new immunosupressive drug, exhibiting its effect through inhibition of proliferation of T- and B-lymphocytes. Superior efficacy of mycophenolate mofetil compared to azathioprine, in combination with cyclosporine and prednisone, in the prevention of acute rejection in organ transplantation has made mycophenolate mofetil one of the standard immunosupressive drugs after transplantation. Mycophenolate mofetil also is an interesting candidate drug for many other, mainly auto-immune mediated diseases. The use of mycophenolate mofetil in several of these diseases is discussed. The definitive place of mycophenolate mofetil will depend on the results of randomised trials currently under way. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：233 / 246

页数：14

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