Nitric oxide prodrugs: Diazeniumdiolate anions of hindered secondary Amines

被引：23

作者：

Chakrapani, Harinath ^{[1
]}

Showalter, Brett M.

Citro, Michael L.

Keefer, Larry K.

Saavedra, Joseph E.

机构：

[1] Natl Canc Inst, Comparat Carcinogenesis Lab, Chem Sect, Ft Detrick, MD 21702 USA

[2] Natl Canc Inst, SAIC Frederick, Basic Res Program, Ft Detrick, MD 21702 USA

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 22期

关键词：

D O I：

10.1021/ol7019636

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

[GRAPHICS] Nitric oxide prodrugs derived from hindered secondary amines were prepared. The decomposition patterns of these prodrugs indicate that alpha-methyl groups around the nitrogen bearing the diazeniumdiolate group prolong their half-life in aqueous buffer.

引用

页码：4551 / 4554

页数：4

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