GRAIL: a unique mediator of CD4 T-lymphocyte unresponsiveness

被引：51

作者：

Whiting, Chan C. ^{[1
]}

Su, Leon L. ^{[1
]}

Lin, Jack T. ^{[1
]}

Fathman, C. Garrison ^{[1
]}

机构：

[1] Stanford Univ, Dept Med, Div Rheumatol & Immunol, Stanford, CA 94305 USA

来源：

FEBS JOURNAL | 2011年 / 278卷 / 01期

关键词：

anergy; cell cycle; de-ubiquitinating enzymes (DUBs); E3; GRAIL; RNF128; T-cell unresponsiveness; tolerance; ubiquitination; ubiquitin-protein ligase; E3 UBIQUITIN LIGASE; CELL TOLERANCE; CUTTING EDGE; CBL-B; UP-REGULATION; ANERGY; INDUCTION; ACTIVATION; MECHANISMS; CD151;

D O I：

10.1111/j.1742-4658.2010.07922.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

GRAIL (gene related to anergy in lymphocytes, also known as RNF128), an ubiquitin-protein ligase (E3), utilizes a unique single transmembrane protein with a split-function motif, and is an important gatekeeper of T-cell unresponsiveness. Although it may play a role in other CD4 T-cell functions including activation, survival and differentiation, GRAIL is most well characterized as a negative regulator of T-cell receptor responsiveness and cytokine production. Here, we review the recent literature on this remarkable E3 in the regulation of human and mouse CD4 T-cell unresponsiveness.

引用

页码：47 / 58

页数：12

共 64 条

[21] Tetraspanin CD151 regulates RhoA activation and the dynamic stability of carcinoma cell-cell contacts [J].

Johnson, Jessica L. ;

Winterwood, Nicole ;

DeMali, Kris A. ;

Stipp, Christopher S. .

JOURNAL OF CELL SCIENCE, 2009, 122 (13) :2263-2273

[22] Tissue- and age-specific changes in gene expression during disease induction and progression in NOD mice [J].

Kodama, Keiichi ;

Butte, Atut J. ;

Creusot, Remi J. ;

Su, Leon ;

Sheng, Deqiao ;

Hartnett, Mark ;

Iwai, Hideyuki ;

Soares, Luis R. ;

Fathman, C. Garrison .

CLINICAL IMMUNOLOGY, 2008, 129 (02) :195-201

[23] Up-regulation of gene related to anergy in lymphocytes is associated with notch-mediated human T cell suppression [J].

Kostianovsky, Alex M. ;

Maier, Lisa M. ;

Baecher-Allan, Clare ;

Anderson, Ana C. ;

Anderson, David E. .

JOURNAL OF IMMUNOLOGY, 2007, 178 (10) :6158-6163

[24] E3 ubiquitin ligase GRAIL controls primary T cell activation and oral tolerance [J].

Kriegel, Martin A. ;

Rathinam, Chozhavendan ;

Flavell, Richard A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (39) :16770-16775

[25] Blocked signal transduction to the ERK and JNK protein kinases in anergic CD4(+) T cells [J].

Li, W ;

Whaley, CD ;

Mondino, A ;

Mueller, DL .

SCIENCE, 1996, 271 (5253) :1272-1276

[26] The role of E3 ligases in autoimmunity and the regulation of autoreactive T cells [J].

Lin, Amy Erica ;

Mak, Tak W. .

CURRENT OPINION IN IMMUNOLOGY, 2007, 19 (06) :665-673

[27] Naive CD4 T Cell Proliferation Is Controlled by Mammalian Target of Rapainaycin Regulation of GRAIL Expression [J].

Lin, Jack T. ;

Lineberry, Neil B. ;

Kattah, Michael G. ;

Su, Leon L. ;

Utz, Paul J. ;

Fathman, C. Garrison ;

Wu, Linda .

JOURNAL OF IMMUNOLOGY, 2009, 182 (10) :5919-5928

[28] The single subunit transmembrane E3 ligase gene related to anergy in lymphocytes (GRAIL) captures and then ubiquitinates transmembrane proteins across the cell membrane [J].

Lineberry, Neil ;

Su, Leon ;

Soares, Luis ;

Fathman, C. Garrison .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (42) :28497-28505

[29] Cutting edge: The transmembrane E3 ligase GRAIL ubiquitinates the costimulatory molecule CD40 ligand during the induction of T cell anergy [J].

Lineberry, Neil B. ;

Su, Leon L. ;

Lin, Jack T. ;

Coffey, Greg P. ;

Seroogy, Christine M. ;

Fathman, C. Garrison .

JOURNAL OF IMMUNOLOGY, 2008, 181 (03) :1622-1626

[30] Immunity by ubiquitylation: A reversible process of modification [J].

Liu, YC ;

Penninger, J ;

Karin, M .

NATURE REVIEWS IMMUNOLOGY, 2005, 5 (12) :941-952

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