The architecture of cognitive control in the human prefrontal cortex

被引：1291

作者：

Koechlin, E

Ody, C

Kouneiher, F

机构：

[1] Univ Paris 06, INSERM, F-75005 Paris, France

[2] Hop La Pitie Salpetriere, F-75013 Paris, France

来源：

SCIENCE | 2003年 / 302卷 / 5648期

关键词：

D O I：

10.1126/science.1088545

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The prefrontal cortex (PFC) subserves cognitive control: the ability to coordinate thoughts or actions in relation with internal goals. Its functional architecture, however, remains poorly understood. Using brain imaging in humans, we showed that the lateral PFC is organized as a cascade of executive processes from premotor to anterior PFC regions that control behavior according to stimuli, the present perceptual context, and the temporal episode in which stimuli occur, respectively. The results support an unified modular model of cognitive control that describes the overall functional organization of the human lateral PFC and has basic methodological and theoretical implications.

引用

页码：1181 / 1185

页数：5

共 30 条

[11]

Friston K. J., 1993, Human Brain Mapping, V1, P69, DOI 10.1002/hbm.460010108

[12] Cholinergic stimulation alters performance and task-specific regional cerebral blood flow during working memory [J].