Palladium-catalyzed multicomponent coupling of alkynes, imines, and acid chlorides: A direct and modular approach to pyrrole synthesis

被引：192

作者：

Dhawan, R ^{[1
]}

Arndtsen, BA ^{[1
]}

机构：

[1] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 02期

关键词：

D O I：

10.1021/ja039152v

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new palladium-catalyzed method to prepare pyrroles directly from three basic building blocks - imines, alkynes, and acid chlorides - is described. This approach provides a straightforward method both to prepare pyrroles in one step and to diversify their structure by simple variation of any of the three starting materials. Mechanistic studies suggest that this process occurs via a complex series of eight individual steps, and this is discussed. Copyright © 2004 American Chemical Society.

引用

页码：468 / 469

页数：2

共 32 条

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