Monocyte recruitment during infection and inflammation

被引：2289

作者：

Shi, Chao ^{[1
]}

Pamer, Eric G. ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, Program Immunol, Infect Dis Serv,Dept Med, New York, NY 10065 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2011年 / 11卷 / 11期

基金：

美国国家卫生研究院;

关键词：

CHEMOKINE RECEPTOR CCR1; MURINE CYTOMEGALOVIRUS-INFECTION; TYPE-3 COMPLEMENT RECEPTOR; MULTIPLE-SCLEROSIS LESIONS; INFLUENZA-VIRUS INFECTION; NODE DENDRITIC CELLS; BACTERIAL-INFECTION; BONE-MARROW; IN-VIVO; IMMUNE-RESPONSES;

D O I：

10.1038/nri3070

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Monocytes originate from progenitors in the bone marrow and traffic via the bloodstream to peripheral tissues. During both homeostasis and inflammation, circulating monocytes leave the bloodstream and migrate into tissues where, following conditioning by local growth factors, pro-inflammatory cytokines and microbial products, they differentiate into macrophage or dendritic cell populations. Recruitment of monocytes is essential for effective control and clearance of viral, bacterial, fungal and protozoal infections, but recruited monocytes also contribute to the pathogenesis of inflammatory and degenerative diseases. The mechanisms that control monocyte trafficking under homeostatic, infectious and inflammatory conditions are being unravelled and are the focus of this Review.

引用

页码：762 / 774

页数：13

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